The Local Lymph Node Assay (LLNA) is the official method for assessing the allergic contact dermatitis potential of chemicals for the purposes of REACH regulation. The LLNA went through a validation process that allowed the delineation of a robust protocol for performing new tests. The OECD accepted this method in 2002 and published OECD TG 429. The European Chemical Agency (ECHA) recently publ...

Radioiodine activity required for remnant thyroid ablation is of great concern, to avoid unnecessary exposure to radiation and minimize adverse effects. We investigated clinical outcomes of remnant thyroid ablation with a low radioiodine activity in Korean patients with low to intermediate-risk thyroid cancer. For remnant thyroid ablation, 176 patients received radioiodine of 1.1 GBq, under a s...

Background: The commissioning accuracy of Volumetric Modulated Arc Therapy (VMAT) need to be evaluated.Objective: To test and evaluate commissioning accuracy of VMAT based on the TG 119 protocols at local institution. Material and Methods: The phantom, structure sets, VMAT and IMRT beam parameter setup, dose prescriptions and planning objectives were following TG 119 guidelines to c...

BACKGROUND Most of the current brachytherapy treatment planning systems (TPS) use the TG-43U1 recommendations for dosimetry in water phantom, not considering the heterogeneity effects. OBJECTIVE The purpose of this study is developing a method for obtaining correction factors for heterogeneity for Cs-137 brachytherapy sources based on pre-calculated MC simulations and interpolation. METHOD ...

In prostate cancer treatment, there is an increasing interest in the permanent radioactive seeds implant technique. Currently, in Brazil, the seeds are imported with high prices, which prohibit their use in public hospitals. A ceramic matrix that can be used as a radioisotope carrier and radiographic marker was developed at our institution. The ceramic matrix is distinguished by the characteris...

1. These Performance Standards (PS) accompany the BG1Luc Estrogen Receptor (ER) Transactivation (TA) Test Method for Identifying ER Agonists and Antagonists (TG 457) (1). Prior to the acceptance of a new test method for regulatory testing applications, validation studies are conducted to assess its reliability (i.e., the extent of intraand inter-laboratory reproducibility over time when perform...

BACKGROUND Aging results in a decline in the function of the respiratory muscles. Inspiratory muscle training is emerging as a possible intervention to attenuate the decline of respiratory muscles in the elderly. The aim of this study was to evaluate the efficacy of inspiratory muscle training on respiratory strength, diaphragm thickness, and diaphragmatic mobility in elderly women. METHODS T...