Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. Reformulation using U.S. Food and Drug Administration-approved esterase and efflux inhibitors to increase oral bioavailability could provide lower dose alternatives and reduce costs for patients with HIV in resource-limited settin...

Dendritic cell (DC)-to-T cell transmission is an example of infection in trans, in which the cell transmitting the virus is itself uninfected. During this mode of DC-to-T cell transmission, uninfected DCs concentrate infectious virions, contact T cells and transmit these virions to target cells. Here, we investigated the efficiency of DC-to-T cell transmission on the number of cells infected an...

BACKGROUND Tenofovir alafenamide (TAF) is a novel investigational prodrug of tenofovir (TFV) that permits enhanced delivery of TFV into peripheral blood mononuclear cells (PBMCs) and lymphatic tissues. A critical step in the intracellular metabolic activation of TAF is mediated by the lysosomal protease cathepsin A (CatA). Here, we investigated CatA levels together with intracellular metabolism...

[1] This study provides a fast and easy‐to‐apply method to estimate threshold friction velocity (TFV) of wind erosion in the field. Wind tunnel experiments and a variety of ground measurements including air gun, pocket penetrometer, torvane, and roughness chain were conducted in Moab, Utah and cross‐validated in the Mojave Desert, California. Patterns between TFV and ground measurements were ex...

Integrated design synthesizes combinations of options to take advantage of interactions that maximize multidisciplinary value. As resources become further constrained, options more numerous and goals increasingly complex, it is more critical and more challenging for design teams to find these integrated solutions. Theory proposes the integration of transformation, flow, and value (TFV) views as...

A great challenge of text mining arises from the increasingly large text datasets and the high dimensionality associated with natural language. In this research, a systematic study is conducted of six Dimension Reduction Techniques (DRT) in the context of the text clustering problem using three standard benchmark datasets. The methods considered include three feature transformation techiques, I...

Human immunodeficiency virus protease inhibitors (PIs) modestly affect the plasma pharmacokinetics of tenofovir (TFV; -15% to +37% change in exposure) following coadministration with the oral prodrug TFV disoproxil fumarate (TDF) by a previously undefined mechanism. TDF permeation was found to be reduced by the combined action of ester cleavage and efflux transport in vitro. Saturable TDF efflu...

INTRODUCTION For access-challenged patients with bilateral upper extremity central venous stenosis, solutions include the Hemodialysis Reliable Outflow (HeRO) device or an autogenous AV fistula in the lower limb. We evaluated HeRO grafts and transpositions of the femoral vein in maintaining primary and secondary patency. METHODS We retrospectively analyzed 40 patients with a HeRO device and 1...