The sense of taste allows animals to detect chemicals in the environment, giving rise to behaviors critical for survival. When Gustatory Receptor Neurons (GRNs) detect tastant molecules, they encode information about the identity and concentration of the tastant as patterns of electrical activity that then propagate to follower neurons in the brain. These patterns constitute internal representa...

Sensory information undergoes substantial transformation along sensory pathways, usually encompassing sparsening of activity. In the olfactory bulb, though natural odorants evoke dense glomerular input maps, mitral and tufted (M/T) cells tuning is considered to be sparse because of highly odor-specific firing rate change. However, experiments used to draw this conclusion were either based on re...

Large-area RF-driven ion source is being developed at Germany for the heating and current drive of ITER device [1, 2]. Negative hydrogen ion sources are major components of neutral beam injection systems in future large-scale fusion experiments such as ITER and DEMO. RF sources for the production of positive hydrogen ions have been successfully developed at IPP (Max-Planck-Institute for Plasma ...

Recent reports in human demonstrate a role of theta-gamma coupling in memory for spatial episodes and a lack of coupling in people experiencing temporal lobe epilepsy, but the mechanisms are unknown. Using multisite silicon probe recordings of epileptic rats engaged in episodic-like object recognition tasks, we sought to evaluate the role of theta-gamma coupling in the absence of epileptiform a...

Information processing and transfer between brain structures have been proposed to engage the phase-locking of neuronal firing to gamma oscillations during certain cognitive functions, including learning and memory. The cellular mechanism behind this precise temporal organisation of action potentials might rely on changes in synaptic strength. Kitanishi et al. (Kitanishi T, Ujita S, Fallahnezha...

BACKGROUND Low- and high-frequency stimulation (LFS and HFS, respectively) have been, reported to modify seizure characteristics in rats. We here report effects of hippocampal LFS and HFS, applied at two or four sites in fully kindled rats. METHODS Rats were kindled through a hippocampal tetrode until the fully kindled state. Animals with, stable afterdischarge (AD) threshold were randomly as...

Spike sorting is an essential first step in most analyses of extracellular in vivo electrophysiological recordings. Here we show that spike-sorting success depends critically on characteristics of coordinated population activity that can differ between anesthetic states. In tetrode recordings from mouse auditory cortex, spike sorting was significantly less successful under ketamine/medetomidine...

The local field potential (LFP), comprised of low-frequency extra-cellular voltage fluctuations, has been used extensively to study the mechanisms of brain function. In particular, oscillations in the gamma-band (30-90 Hz) are ubiquitous in the cortex of many species during various cognitive processes. Surprisingly little is known about the underlying biophysical processes generating this signa...

Devices in which a controlled flow of electrons can be obtained are the basic building blocks of all the electronic circuits. Before the discovery of transistor in 1948, such devices were mostly vacuum tubes (also called valves) like the vacuum diode which has two electrodes, viz., anode (often called plate) and cathode; triode which has three electrodes – cathode, plate and grid; tetrode and p...

We examine the responses of single neurons and pairs of neurons, simultaneously recorded with a single tetrode in the primary visual cortex of the anesthetized macaque monkey, to transient presentations of stationary gratings of varying spatial phase. Such simultaneously recorded neurons tended to have similar tuning to the phase of the grating. To determine the response features that reliably ...