Abbreviations: ALS: Amyotrophic Lateral Sclerosis; ATP: Adenosine Triphosphate; CBS: Cystathionine β-Synthase; CNS: Central Nervous System; COMT: Catechol-O-Methyl-Transferase; CYP2E1: Cytochrome P450 2E1; eNOS: Endothelial Nitric Oxide Synthase; Hcy: Homocysteine; L-DOPA: Levodopa; mPT: Mitochondrial Permeability Transition; MPTP: 1-Methyl 4-Phenyl 1,2,3,6-Tetrahydropyridine; MTHFR: Methylene ...

Due to both the requirements of repeated complex organic synthesis and tedious biochemical verification experiments for screening new photosensitizers, development a satisfactory photosensitizer with excellent photosensitivity highly specific response ability is still great challenge accurate imaging localization precise photodynamic therapy (PDT) tumors. Herein, under help theoretical calculat...

Abstract The early diagnosis of Parkinson's disease (PD) provides opportunities for intervention to slow the progression neurological degeneration in patients, particularly as aging population increases our society. Among a series pathological features PD, mitochondria abnormalities have been identified central event that occurs at stage PD. However, method detecting mitochondrial abnormalities...

Parkinson disease (PD) is the second most common neurodegenerative disorder, whose prevalence 2~3% in population over 65. ?-Synuclein aggregation major pathological hallmark of PD. However, recent studies have demonstrated enhancing evidence tau pathology Despite extensive considerations, thus far, actual spreading mechanism neurodegeneration has remained elusive a PD brain. This study aimed to...

Abstract Background ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, its defection plays an important role pathogenesis. To reveal etiological implication ANT1 for Parkinson’s disease (PD), a neurodegenerative disorder, mouse model treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroblastoma cell induced by 1-methyl-4-pehny1-pyridine we...

Parkinson's disease (PD) is a common neurodegenerative disorder with no cure. Astragalus membranaceus used in Chinese culture as food supplement to boost immunity. The present study aimed explore the neuroprotective effects of total flavonoids extracted from A. (TFA) and their protective mechanisms. TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPT...