purpose the aim of this study was to compare the levels of serum immunoglobulin (iga, igm, igg), testosterone and cortisol in semi-endurance elite runners during general preparation and competition phase of training. methods thirteen semi-endurance elite male runners with an average age of 18.92±1.7 years volunteered to take part in this study. the runners participated in the selected training ...

background: toxoplasma gondii is an intracellular protozoan parasite that infects human and animals. toxoplasma parasites are isolated from different parts of ani-mals even from semen but there are little information about the effect of toxo-plasmosis on fertility in animals and humans. in present study, the effect of chronic toxoplasmosis on serum levels of testosterone in men was studied. met...

The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activational effects of testosterone in adulthood, and any interactions on regional volum...

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo r...

A young female with prolonged intermenstrual bleeding was found to have raised total plasma testosterone of 25.8 nmol/l (NR<2.9 nmol/l) using the Roche Elecsys Testosterone I immunoassay without clinical features of virulisation. Few months ago investigations for lethargy and low libido had shown normal total testosterone of 0.8 nmol/l. Further history revealed that she was using maca extract t...

Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injec...

Enzyme immunoassays (EIAs) are widely used to measure salivary testosterone. However, little is known about how accurately different EIAs assess testosterone, partially because estimates across various EIAs differ considerably. We compared testosterone concentrations across EIAs of three commonly used manufacturers (DRG International, Salimetrics, and IBL International) to liquid chromatography...

The association between testosterone and economic risk is not well-understood and is understudied. The present study aimed to further characterize what if any relationship testosterone has with risky economic decisions. To do so, 154 participants (78 men) completed the Iowa Gambling Task (IGT) (Bechara et al., 1994) and also provided saliva samples, which were assayed for endogenous testosteron...

Testosterone deficiency is a common and often unrecognized disorder impacting the lives of many men. Symptoms related to low testosterone are relatively non-specific and clinicians must therefore ensure that a patients' symptomatology is supported by a biochemical profile suggestive of testosterone deficiency. There are many options available to determine a patient's testosterone level and labo...

The treatment algorithm for metastatic prostate cancer has changed more in the last decade than previous 50 years. Testosterone suppression many years been gold standard men newly diagnosed with cancer. However, randomised studies have now shown that escalation of therapy beyond testosterone depletion results profound and clinically meaningful survival benefits. This review aims to summarise la...