Higher temperatures lead to an increase of testicular metabolism that results in spermatic damage. Oxidative stress is the main factor responsible for testicular damage caused by heat stress. The aim of this study was to evaluate lasting effects of heat stress on ejaculated sperm and immediate or long-term effects of heat stress on epididymal sperm. We observed decrease in motility and mass mot...

BACKGROUND The aim of our study was to review the results of microsurgically performed testicular sperm extraction (TESE) and to evaluate its possible long term effects on serum testosterone (T). METHODS We operated on 48 men (35 +/- 8 years) with non-obstructive azoospermia (NOA). If no spermatozoa were found following a micro epididymal sperm extraction (Silber et al., 1994) and testicular ...

sperms are highly specialized cells for delivering dna from male to the ovum. incredibly, wide degree of diversity in sperm morphology in their basic structures i.e. head, middle piece and tail is found across species. differences in terms of overall size of the sperm, shape and number of sperm produced are also incredible. one of the key for this variations or diversity in sperm may be associa...

background: testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (ir) injury. therefore the present study aims at producing new drugs for the treatment of testicular ir injury. methods: 42 an...

OBJECTIVES To review a large experience with sperm cryopreservation in patients with testicular cancer and determine the effect of clinical stage and tumor histologic features on semen quality. METHODS The prefreeze and post-thaw sperm quality of 157 patients with testicular cancer was compared with that of 50 normal donors. The impact of tumor stage and histologic features (pure seminoma, pu...

From 1 August 1993 until 30 September 1994, 69 couples suffering from azoospermia underwent testicular sperm extraction and intracytoplasmic sperm injection. In 50 couples with obstructive azoospermia a total of 631 metaphase-II oocytes were injected after testicular sperm extraction yielding a 2-PN fertilization rate of 57%. In female patients <40 years of age an ongoing pregnancy rate per tra...

Received on: April 28, 2009 – Accepted on: Oct 15, 2009 aBstRact Azoospermia is defined as the absence of mature spermatozoa in semen analysis after centrifugation. The causes of azoospermia may be related to spermatogenesis defects and classified as nonobstructive azoospermia, or to the obstruction of the efferent ducts of the genital tract and classified as obstructive azoospermia. Before the...

Despite of many benefits of nanoparticles induced, their increasing usage raises concern about the consequences and health threats that it might bring to humans. So, the current study evaluated the testicular defects after i.p. injection of silver naoparticles (AgNPs). Male mice, weighing 31-34 g, and of 3 months old were randomly assigned into three groups with respect to concentration of nano...

BACKGROUND Testicular sperm retrieval can lead to paternity for azoospermic patients with spermatogenic failure. The human BOULE gene, a meiotic regulator of germ cells, is a gene whose altered expression may be associated with sterility. We determined the levels of BOULE transcripts in the testes of azoospermic patients, and evaluated the relationship between BOULE transcript levels and patien...

The identification and characterization of germ cell-specific genes are essential if we hope to comprehensively understand the mechanisms of spermatogenesis and fertilization. Here, we searched the mouse UniGene databases and identified 13 novel genes as being putatively testis-specific or -predominant. Our in silico and in vitro analyses revealed that the expressions of these genes are testis-...