After infection of male mice with the plerocercoids (spargana) of Spirometra mansoni, serum levels of estrogen and testicular weight were analyzed by enzyme-linked immunosorbent assay (ELISA) and weighing machine, respectively. The serum level of estrogen increased progressively in infected mice compared with normal controls, whereas the testicular weight of infected mice decreased significantl...

BACKGROUND Sox9 (Sry box containing gene 9) is a DNA-binding transcription factor involved in chondrocyte development and sex determination. The protein's absence in testicular Sertoli nurse cells has been shown to disrupt testicular function in adults but little is known at the genome-wide level about molecular events concomitant with testicular break-down. METHODS To determine the genome-wi...

Complete Androgen Insensitivity Syndrome (CAIS) is a rare X-linked recessive disorder. Patients have 46 XY karyotype, and the external genitalia of normal female. In this manuscript, we describe nine year old child diagnosed at three years age with Autoimmune Polyendocrine type-1 (APS-1). The was female no hernia. Parents initially declined any endocrine disorder in family. Genetic study, which...

Our laboratory has shown that the Y chromosome has a significant effect on blood pressure in the spontaneously hypertensive rat (SHR) model of hypertension and that the testes and androgen receptor contribute to the blood pressure rise. As an extension of our research, we have developed two new rat strains, SHR/a and SHR/y (F11) to study the Y chromosome. The objectives of the following researc...

Female mice heterozygous for testicular feminization were sex-reversed by means of the autosomal sex reversal mutation {Sxr). Due to X-inactivation, the blastemata for male sex organs in these animals are composed of a mixture of cells, carrying either the wildtype X chromosome or the X chromosome affected with Tfm in an active state. Thus, the two types of cells are sensitive to androgens or i...

3H-DHT binding was examined in cultured skin fibroblasts from a patient with complete testicular feminisation (CTF), from his heterozygote mother, and his clinically normal sister, who menstruated normally. Binding parameters were: Bmax less than 1 fmol/mg protein and KD unmeasurable in CTF; Bmax = 24 fmol/mg protein and KD = 3.63 X 10(-9) mol/l in the mother; and Bmax = 46 fmol/mg protein and...

Recently we had ani opportunity to study the biochemistry of 2 cliniical conditions leading to feminization: one due to an adrenal tumor and the other to abnormal testicular tissue. In the 1st imistance, the biosynthesis of estrogens from pregnenolone and progesterone imian adrenal tumor was demonstrated for the 1st time. In the 2nd study, estrogen biosynthesis was demonstrated by homogenates o...

OBJECTIVE To objectively assess the results of rhinoplasty in feminizing the facial profiles of male-to-female transsexual patients undergoing gender reassignment. METHODS Twelve patients underwent nasal feminization as part of male-to-female gender reassignment. Global assessments of facial profile were performed, and nasofrontal, nasolabial, and supratip angles and the Goode ratio were obje...

Foreword William Pollin Plenary Session Presentation to Kay Croker of J. Michael Morrison Award for Outstanding Achievement in Science Administration in the Drug Field Martin W. Adler Introduction of Nathan B. Eddy Memorial Award Recipient--1984 Louis S. Harris The Analgesic Connection: The Nathan 8. Eddy Memorial Lecture Raymond W. Houde Symposium Opiate and Opioid Modulation of Reproductive E...