OBJECTIVES To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms.  Methods: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center...

Benzodiazepines and benzodiazepine receptor agonists (e.g., zaleplon [Sonata], zolpidem [Ambien]) are widely used to treat anxiety and insomnia, even though antidepressants are first-line therapy for anxiety disorders based on the evidence.1 In this issue of American Family Physician, Drs. Ramar and Olson review the management of insomnia and other sleep disorders.2 When benzodiazepines are use...

Bisphosphonates are widely used for the prevention of osteoporosis-associated fractures. Femoral fractures associated with bisphosphonate use are increasingly being reported in the literature. Orthopedic surgeons should be aware of this potential association and related implications for patient treatment. Bisphosphonate-associated fractures are characteristically simple, transverse with beaking...

Computer applications are designed, used, and assessed by (often unstated) analogy to other tools and devices. When viewed as appliances (e.g., telephones), applications are created and judged according to standards of ease of use and rapid learnability; when viewed, by contrast, as creative media (e.g., musical instruments), standards expressiveness and flexibility become more salient. In desi...

Correspondence: Alexandros A Drosos Professor of Medicine, Head of Rheumatology Clinic, Rheumatology Clinic, Department of internal Medicine, Medical School, University of ioannina, 45110, ioannina, Greece Tel +3

There is intense antimicrobial use in long-term-care facilities (LTCF), and studies repeatedly document that much of this use is inappropriate. The current crisis in antimicrobial resistance, which encompasses the LTCF, heightens concerns of antimicrobial use. Attempts to improve antimicrobial use in the LTCF are complicated by characteristics of the patient population, limited availability of ...

This paper studies two roles that long-term nominal interest rates can play in the conduct of monetary policy in a New Keynesian model. The first allows long-term rates to enter the reaction function of the monetary authority. The second considers the possibility of using long-term rates as instruments of policy. It is shown that in both cases a unique rational expectations equilibrium exists. ...

[No Abstract Available].

Ma Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular drug classes: aspirin, statins, betablockers, and angiotensin-converting enzym...