There is a consensus emerging on the importance of upstream ethical engagement in nanobiotechnology. Such a preventive ethic would anticipate downstream concerns that might arise and mitigate them as part of the research and development process. However, there is an unappreciated tension between the time horizon of upstream ethics and that assumed by most bioethical research. Current standards ...

A Hamiltonian framework is introduced to encompass non-rotating (but possibly charged) black holes that are “isolated” near future time-like infinity or for a finite time interval. The underlying space-times need not admit a stationary Killing field even in a neighborhood of the horizon; rather, the physical assumption is that neither matter fields nor gravitational radiation fall across the po...

Standard cosmological equations are written for the Hubble volume, while real boundary of space-time is event horizon. Within unimodular and thermodynamic approaches to gravity, dark energy term in appears as an integration constant, which we fix at horizon obtain observed value constant.

In open-pit mining operations, there are several levels of planning, each of which passes down restrictions to the level below. Each planning task is to determine the order in which material should be mined and how it should be processed, such that blending and utilisation targets are met. The mining operations are subject to various constraints on equipment use, maintenance and other resources...

Careful tuning of the learning rate, or even schedules thereof, can be crucial to effective neural net training. There has been much recent interest in gradient-based meta-optimization, where one tunes hyperparameters, or even learns an optimizer, in order to minimize the expected loss when the training procedure is unrolled. But because the training procedure must be unrolled thousands of time...

This paper addresses the design of a dynamic state feedback receding horizon controller, which guarantees robust constraint satisfaction, robust stability and offset-free control of constrained linear systems in the presence of time-varying setpoints and unmeasured disturbances. This objective is obtained by first designing a dynamic linear offset-free controller and computing an appropriate do...

This paper further explores the horizon e®ect in the optimal static and dynamic demand for risky assets under return predictability as documented by Barberis (2000). Contrary to the case of stocks, the optimal demand for longterm Government bonds of a buy-and-hold investor is not necessarily increasing in the investment horizon, and may in fact be decreasing for some initial levels of the predi...

Modelling A model was used to combine the available clinical and cost data with the patient population survival data in order to estimate the cost-effectiveness of the treatment options. On account of the limited time horizon of the trials, data were extrapolated to reflect the long-term cost-effectiveness of the interventions. The consequences of the intervention were modelled for both a short...