The literature on the long-term effects of nutritional deficiencies in early life is reviewed. The severity and duration of the deficiency, the stage of the children's development, the biological condition of the children and the socio-cultural context may all modify the effect. There is substantial evidence that reduced breast-feeding, small-for-gestational-age birth weight, Fe and I deficienc...

The main aspects of infant feeding that have been studied in humans in association with the subsequent development of adipose tissue include breastfeeding, rapid infancy weight gain, and weaning practices. While observational studies have consistently shown a protective effect of breastfeeding on the development of obesity, these studies may be confounded by unmeasured or unknown factors, as su...

In this retrospective study, using the prospectively collected database of the AO-Documentation Centre, we analysed the outcome of 57 malunited fractures of the ankle treated by reconstructive osteotomy. In all cases the position of the malunited fibula had been corrected, in several cases it was combined with other osteotomies and the fixation of any non-united fragments. Patients were seen on...

Bj6rk-Shiley Spherical-Disc Valves have been one of the most commonly used mechanical valves in the past 20 years. The long-term mortality and complications of these valves is therefore of great interest to the life insurance medical director. This paper presents an unusually complete set of data and additional follow-up of two earlier separate articles on long-term follow-up of aortic and mitr...

OBJECTIVE The goal of this study has been to determine whether hyaluronic acid (HA) or exercise therapy can improve functional parameters in patients with osteoarthritis (OA) of the ankle. METHODS In a prospective clinical trial, 43 ankles (30 patients) with radiographic Kellgren Lawrence grade III OA were randomized to receive three intra-articular HA injections, with one-week interval of or...

OBJECTIVE To evaluate whether a mixed population of patients treated with Intensive Short-term Dynamic Psychotherapy (ISTDP) would exhibit reduced healthcare costs in long-term follow-up. METHODS A quasi-experimental design was employed in which data on pre- and post-treatment healthcare cost were compared for all ISTDP cases treated in a tertiary care service over a nine year period. Observe...

CONTEXT Short-term data on the immunogenicity of monoclonal antibodies showed associations between the development of antidrug antibodies and diminished serum drug levels, and a diminished treatment response. Little is known about the clinical relevance of antidrug antibodies against these drugs during long-term follow-up. OBJECTIVE To examine the course of antidrug antibody formation against...

The lateral substitution reconstruction operation described by MacIntosh has been evaluated in 27 patients with chronic anterior cruciate ligament deficiency of the knee. The results, at an average of 11.3 years after operation, have been assessed by a scoring system which allocates a maximum of 25 points each for function and for clinical evaluation. Emphasis was placed on subjective giving wa...

OBJECTIVES The aim of this study was to assess the long-term stability of treatment with self-ligating brackets compared with conventional brackets. MATERIALS AND METHODS The long-term follow-up retrospective study sample consisted of two groups of patients: group SL (including passive and interactive self ligating braces) comprised 30 subjects treated with self-ligating brackets at a mean pr...

BACKGROUND Previous follow-up studies of repeated self-harm show that the cumulative risk of repeated self-harm within one year is 5.7%-15%, with females at greatest risk. However, relatively few studies have focused on the Far East. The objective of this study was to calculate the cumulative risk of repeated self-harm over different lengths of follow-up time (3 months, 6 months, and 1-8 years)...