The pathogenesis of lupus nephritis is mainly attributable to a complex interaction between the innate and adaptive immune systems, including T and B cell function abnormalities. In addition to autoantibody production and immune complex deposition, Th1 and Th17 cytokines may play key roles in the development and progression of lupus nephritis. Acute onset of severe lupus nephritis remains a cha...

Peripheral arterial disease, particularly critical limb ischemia, is an area with urgent need for optimized therapies because, to date, vascular interventions often have limited life spans. In spite of initial encouraging technical success after femoropopliteal percutaneous transluminal angioplasty or stenting, postprocedural restenosis remains the major problem. The challenging idea behind the...

A prospective, single-blind, randomized, multicenter trial (entry dates not mentioned). After successful predilation with a high-pressure balloon of stenotic lesions in failing hemodialysis arteriovenous fistulas (AVFs), 152 patients underwent treatment drug-coated (DCB) and 148 standard (SB) at 29 international sites. The 6-month target lesion patency was significantly greater the treated DCB ...

Fairness in a data center by Mikkel Hagen University of New Hampshire, December, 2012 Existing data centers utilize several networking technologies in order to handle the performance requirements of different workloads. Maintaining diverse networking technologies increases complexity and is not cost effective. This results in the current trend to converge all traffic into a single networking fa...

Background and Purpose—Neuronal Na/Ca exchanger plays a relevant role in maintaining intracellular Ca and Na levels under physiological and pathological conditions. However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes. Methods—We investigated the effects of bepridil and 39,49-di...

An experimental study to characterize properties controlling delamination of paperboard is presented. The normal and shear traction–separation laws are measured evaluated using a double cantilever beam (DCB) split (SCB) specimen. DCB-experiments provides separation data in good agreement with results alternative techniques. From the data, both fracture resistance obtained. A length parameter in...

Developing cotton (Gossypium hirsutum) fibers, cultured in vitro with their associated ovules, were used to compare the effects of two herbicides that inhibit cellulose synthesis: 2,6-dichlorobenzonitrile (DCB) and an experimental thiatriazine-based herbicide, CGA 325'615. CGA 325'615 in nanomolar concentrations or DCB in micromolar concentrations causes inhibition of synthesis of crystalline c...

Two different markers for quantitating cell proliferation were evaluated in livers of control and chemically treated mice and rats. Proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, and bromodeoxyuridine (BrdU), an exogenously administered DNA precursor label, were detected in formalin-fixed, paraffin-embedded tissues using immunohistochemical techniques. The per...

As a cell source with large quantity and easy access, peripheral blood mesenchymal stem cells (PBMSCs) were isolated and seeded in porcine demineralized cancellous bone (DCB) scaffolds, cultured in chondrogenic medium and evaluated for in vitro chondrogenesis. Bone marrow MSCs (BMMSCs) and articular cartilage chondrocytes (ACCs) underwent the same process as controls. The morphology, viability ...