Introduction . The introduction of chimeric antigen receptor (CAR) T-cell therapy is a promising treatment patients with relapsed or refractory (R/R) B-cell lymphoproliferative diseases (LPDs). Aim — to present the results CAR-T-cell 6 adult LPDs. Materials and methods This pilot study conducted in R/R persistent minimal residual disease LPDs treated CAR-T-cells. was approved by local ethical c...

the management of intracranial mass lesions. Neurosurgery 1983;12: 277-85. 31 Cohadon F. Indications for surgery in the management ofgliomas. Adv Tech Stand Neurosurg 1990;17:189-234. 32 Coffey RJ, Dunsford LD, Taylor FH. Survival after stereotaxic biopsy of malignant gliomas. Neurosurgery 1988;22:465-73. 33 Newall J, RansohoffJ, Kaplan B. Glioblastoma in the older patient: how long a course of...

BACKGROUND Dendritic cells (DC) and regulatory cells (Treg) play pivotal roles in controlling both normal and autoimmune adaptive immune responses. DC are the main antigen-presenting cells to T cells, and they also control Treg functions. In this study, we examined the frequency and phenotype of DC subsets, and the frequency and function of Treg from patients with ANCA-associated vasculitis (AA...

Grand ChallenGes The question of self–non-self discrimination, and thereby immunological tolerance, is as old as our appreciation of the receptor-diversity in the immune system. Initially negative selection of self-reactive lymphocytes by clonal deletion in primary lymphoid organs, enhanced by promiscuous expression of ectopic antigens in these organs, attracted attention. It became clear, howe...

The thymidine (dThd) and hypoxanthine (Hyp) requirements for protection of normal human granulocyte-macrophage col ony-forming units, B-, and T-cells against methotrexate-induced inhibition of proliferation were compared to require ments of three malignant solid-tumor cell lines recently estab lished from human tumor xenografts and of the CCRF-CEM Tcell leukemia. In the presence of excess Hyp, ...

In August 2009, a 57-yr-old male smoker (30 pack-yrs) without medical history was diagnosed as having a melanoma of the left shoulder. A complete surgical excision was performed. The lesion was ulcerated. Breslow’s thickness was 1.034 mm and Clark’s level was III. As the axillary sentinel lymph node was positive for tumour cells, an additional lymphadenectomy was performed. The disease was fina...

Objectives: Human gd T lymphocytes can recognise and kill non-small-cell lung cancer cells by Vg9Vd2 T-cell receptor and/or NKG2D. We have established large-scale ex vivo expansion of gd T cells by zoledronate and interleukin-2. This pilot feasibility study evaluates the safety and potential anti-tumour effects of activated autologous gd Tcells administered intravenously to patients. Methods: P...

BACKGROUND Type 1 diabetes in humans is an autoimmune disease in which Tcells target pancreatic islets of Langerhans, leading to the progressive destruction of the insulin-producing beta cells. Both genetic and environmental factors contribute to the development of autoimmune diabetes. The non-obese diabetic (NOD) mouse model of human type 1 diabetes demonstrates two missense mutations in the t...

introduction: decidua as the nearest mother's tissue layer to the fetus which is in direct contact with the embryo has an important role in composing the appropriate microenvironment for protection of allogenic fetus from mother's immune response. in this study the effect of supernatant from culture of decidual cells on dendritic cells regarding the induction of t-cell allogenic proliferation r...

BACKGROUND HIV/AIDS is one of twenty first century's challenges to human being with protean manifestation affecting nearly all organs of our body. It is causing high morbidity and mortality especially in sub-Saharan Africa with numerous ocular complications and blindness. The purpose of this study was to determine the patterns of ocular manifestations of HIV/AIDS and their correlation with CD4+...