Polybrominated diphenyl ethers (PBDEs) have been shown to disrupt thyroid hormone (TH) functions on experimental animals, and one of the proposed disruption mechanisms is the competitive binding of PBDE metabolites to TH transport proteins. In this report, a nonradioactive, site-specific fluorescein-thyroxine (F-T4) conjugate was designed and synthesized as a fluorescence probe to study the bin...

Low-energy moir\'e flat bands in magic-angle twisted bilayer graphene (tBG) have demonstrated incredible potential to exhibit rich exotic quantum phenomena. Theoretically, the of tBG are based on extended structures, i.e., patterns with periodic boundary conditions. However, a fundamental question whether can exist reduced structure symmetry, such as sample edges, remains unanswered. Here, via ...

The release of hormones from thyroxine-binding globulin (TBG) and corticosteroid-binding globulin (CBG) is regulated by movement of the reactive center loop in and out of the β-sheet A of the molecule. To investigate how these changes are transmitted to the hormone-binding site, we developed a sensitive assay using a synthesized thyroxine fluorophore and solved the crystal structures of reactiv...

Salmonellosis is a common healthcare-associated infection in large-animal hospitals, and surveillance for Salmonella is an integral part of comprehensive infection control programmes in populations at risk. The present study compares the effectiveness of two culture techniques for recovery of Salmonella from environmental samples obtained in a large-animal referral veterinary hospital during a ...

CONTEXT The Dutch T(4)-TSH-TBG-based neonatal screening program detects patients with congenital hypothyroidism (CH) of thyroidal (CH-T) as well as central (CH-C) origin. The numbers and characteristics of true-positive and false-positive referrals will differ from other, predominantly TSH-based, screening methods. OBJECTIVE The present study describes the characteristics of the referred neon...

Twisted bilayer graphene (TBG) realizes a highly tunable, strongly interacting system featuring superconductivity and various correlated insulating states. We establish gate-defined wires in TBG with proximity-induced spin-orbit coupling as $(i)$ tool for revealing the nature of insulators $(ii)$ platform Majorana-based topological qubits. In particular, we show that band structure wire immerse...

Moir\'e materials, and in particular twisted bilayer graphene (TBG), exhibit a range of fascinating phenomena that emerge from the interplay band topology interactions. We show nonlinear second-order photoresponse is an appealing probe this rich interplay. A dominant part shift current, which determined by geometry electronic wave functions carrier properties thus becomes strongly modified elec...

We analytically describe the plasmonic edge modes for an interface that involves twisted bilayer graphene (TBG) or other similar Moire van der Waals heterostructure. For this purpose, we employ a spatially homogeneous, isotropic and frequency-dependent tensor conductivity which in principle accounts electronic electrostatic interlayer couplings. predict mode dispersion relation explicitly depen...

Three methods for estimating free thyroxine (FT4) in serum were studied: equilibrium dialysis, the SPAC-ET FT4 radioimmunoassay kit, and the Amerlite MAB FT4 luminometric assay. Serum samples from 10 subjects with above-normal thyroxine-binding globulin (TBG), 6 with low TBG, 30 with familial dysalbuminemic hyperthyroxinemia (FDH), 13 with nonesterified fatty acids (NEFA) concentrations in seru...