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During lactation, female small mammals frequently reduce their fat reserves to very low levels. The function of this reduction is unclear, as calculations suggest that the contribution of the withdrawn energy from fat to the total energy balance of lactation is trivial. An alternative hypothesis is that reducing fat leads to a reduction in circulating adipokines, such as leptin, that play a rol...
Hayton, Samantha M., Tony Kriss, Angie Wade, and David P. R. Muller. Effects on neural function of repleting vitamin E–deficient rats with -tocopherol. J Neurophysiol 95: 2553–2559, 2006. First published January 4, 2006; doi:10.1152/jn.00842.2005. A severe and chronic deficiency of vitamin E ( -tocopherol) is associated with a characteristic neurological syndrome with typical “clinical,” neurop...
Vascular growth factors play an important role in maintaining the structure and integrity of the glomerular filtration barrier. In healthy adult glomeruli, the proendothelial survival factors vascular endothelial growth factor-A (VEGF-A) and angiopoietin-1 are constitutively expressed in glomerular podocyte epithelia. We demonstrate that this milieu of vascular growth factors is altered in stre...
OBJECTIVE To describe profound hypokalemia in a comatose patient with diabetic ketoacidosis. METHODS We present a case report, review the mechanisms for the occurrence of hypokalemia in diabetic ketoacidosis, and discuss its management in the setting of hyperglycemia and hyperosmolality. RESULTS A 22-year-old woman with a history of type 1 diabetes mellitus was admitted in a comatose state....
Green tea contains folate and epigallocatechin gallate (EGCg), which is suggested to be an antifolate. In this study, we examined whether green tea was a good source of folate in a folate depletion/repletion rat model. Rats fed a folate deficient diet for 4 weeks were supplied with folate for 7 days, and then folate repletion effects were evaluated in terms of increase in total folate level in ...
Under certain pathological conditions such as cerebral ischemia and reperfusion the occurrence of free radicals is remarkably increased. However, only very little information is available on their quantitative relevance for the pathophysiology and final outcome of diseases. The aim of the present study was to evaluate the contribution of oxygen radicals in the pathogenesis of a stroke. For this...
In a two-bottle choice test, rats drank more of the fluid having a novel odour than that having an odour which had previously been presented in the later part of meals on concentrated maltodextrin solution. Rats are normally more averse to a novel odour than to a familiar odour; therefore, the conditioned reaction to the odour acquired in these circumstances is likely to be an ingestive aversio...
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers (staurosporin and CD95 stimulation) changed from apoptosis to necrosis, when cells were preemptied of adenosine triphosphate (ATP). Nuclear condensation and DNA fragmentation did not occur in cells predepleted ...
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