We examined the influence of 3 consecutive days of high-intensity cycling on blood and urinary markers of oxidative stress. Eight highly-trained male cyclists (VO2 max 76 +/- 4 mL.kg-1.min-1; mean +/- SD) completed an interval session (9 exercise bouts lasting 30 s each, at 150% peak power output) on day 1, followed by 2 laboratory-simulated 30 km time trials on days 2 and 3. The cyclists also ...

TAS-102 is a novel oral nucleoside antitumor agent containing trifluridine (FTD) and tipiracil hydrochloride (TPI). The compound improves overall survival of colorectal cancer (CRC) patients who are insensitive to standard chemotherapies. FTD possesses direct antitumor activity since it inhibits thymidylate synthase (TS) and is itself incorporated into DNA. However, the precise mechanisms under...

OBJECTIVE The purpose of the present study was to investigate the relationship between the Total Atherosclerotic Score (TAS), a measurement of the overall atherosclerotic burden of the arterial tree by whole body magnetic resonance angiography (WBMRA), and the risk of major adverse cardiovascular events (MACE), defined as cardiac death, myocardial infarction, stroke and/or coronary revasculariz...

It is unclear to what degree depersonalization disorder (DPD) and alexithymia share abnormal brain mechanisms of emotional dysregulation. We compared cerebral processing of facial expressions of emotion in individuals with DPD to normal controls (NC). We presented happy and sad emotion expressions in increasing intensities from neutral (0%) through mild (50%) to intense (100%) to DPD and non-re...

BACKGROUND Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention....

Pneumococcal infections cause up to 2 million deaths annually and raise a large economic burden and thus constitute an important threat to mankind. Because of the increase in the antibiotic resistance of Streptococcus pneumoniae clinical isolates, there is an urgent need to find new antimicrobial approaches to triumph over pneumococcal infections. Toxin-antitoxin (TA) systems (TAS), which are p...

OBJECTIVES We assessed lymphocyte DNA damage and total antioxidant status (TAS) in patients with white-coat hypertension (WCH) and sustained hypertension (SHT). STUDY DESIGN The study included 23 patients (14 females, 9 males; mean age 46+/-6 years) with WCH, 21 patients (13 females, 8 males; mean age 45+/-7 years) with newly diagnosed SHT, and 19 age- and sex-matched healthy volunteers as co...

Amaç: Koronavirüs hastalığı 2019 (COVID-19), küresel halk sağlığını tehdit eden ve bir pandemiye yol açan karmaşık hastalık olmasına rağmen, hastalığın patogenezinde yer alan pro-oksidan/oksidan dengesizliğinin katkıları yeterince araştırılmamıştır. Bu nedenle, bu çalışmanın amacı, COVID-19 hastalarında sigara kullanımının oksidatif stres antioksidan savunma sistemi biyobelirteçleri üzerindeki ...

Increasing evidence supports the clinical view that alexithymia is associated with disturbed dreaming. However, a consistent, replicable pattern of relationships between alexithymia and different dreaming components has not yet been identified. Groups of sleep-disordered outpatients (N 580; 46.0 13.2 years) and nonclinical controls (N 145; 22.9 4.2 years) were administered the Toronto Alexithym...

BACKGROUND This study sought to better define the immunological impact of combining neoadjuvant total androgen suppression (TAS) with radiotherapy (xRT) in treating prostate cancer. MATERIALS AND METHODS Subjects selected (n = 37) were stage I-II prostate cancer patients meeting the eligibility requirements for RTOG protocols 94-08 or 94-13. Flow cytometric monitoring of circulating T helper ...