Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear. We devised a robust genomic metric able to identify cancers with a chromotype called tandem duplicator phenotype (TDP) characterized by frequent and distribu...

The dynamical behavior of a FPSO system in a tandem configuration with a shuttle vessel under the action of wind and current forces can be quite complex. In order to obtain a general view of the problem, an overall picture of the dynamics involved is obtained through a systematic numerical study of equilibria and their stability properties. Environmental parameters such as wind and current spee...

A framework was developed for preliminary evaluation of the relative media replacement costs of three alternative column configurations used for adsorption systems with two vessels, such as those serving small systems. The media replacement cost is the cost of fresh media and the replacement service cost (including transportation, labor, and other non-material costs). Cost normalization methods...

Figure 1. a) Two diodes connected in parallel with the anodes of the two diodes connected together and the cathodes connected together. b) Schematic of the three-terminal device and the dotted squares on Polymer solar cells are a promising alternative to future photovoltaic applications due to various advantages such as low cost and ease of processing. Ever since the invention of bulk heterojun...

tandem metacentric compound X chromosome is composed of two X chromoA somes attached to a medially located centromere and arranged in tandem sequence so that the synaptic configuration is a spiral (NOVITSKI 1954). An approximation to the tandem metacentric has been achieved by the construction of an attached-X heterozygous for Zn(l)y4 ( SIDOROV, SOKOLOV and TROFIMOV 1936; STURTEVANT and BEADLE ...

background: the variable numbers of tandem-repeat (vntr) alleles at the phenylalanine hydroxylase (pah) gene have been used in carrier detection and prenatal diagnosis in phenylketonuria families. this study was carried out to analyze vntr alleles at the pah gene in iranian azeri turkish population. methods: in this study, 200 alleles from general population were studied by pcr. results: the fr...

objective: classic cell culture and karyotyping is routinely used for prenatal detection of different chromosomal abnormalities. molecular cytogenetic techniques have also recently been developed and used for this purpose. quantitative florescence pcr using short tandem repeat (str) markers has more potential for high throughput diagnosis. marker heterozygosity in short tandem repeats (str) is ...

introduction: the secondary genetic changes other than the pml-rara fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia (aml). however, the prognostic significance of flt3 mutations in acute promyelocytic leukemia (apl) is not firmly established....

Miniature inverted-repeat transposable elements (MITEs) are nonautonomous transposons (devoid of the transposase gene tps) that affect gene functions through insertion/deletion events. No transposon has yet been reported to occur in “Candidatus Liberibacter asiaticus,” an alphaproteobacterium associated with citrus Huanglongbing (HLB, yellow shoot disease). In this study, two MITEs, MCLas-A and...

This paper presents a new energy-harvesting system with two identical piezoelectric energy harvesters in a tandem configuration. Each harvester consists of a piezoelectric beam and a circular cylinder. Experiments are performed to investigate the energy-harvesting performances of this system in water. It can be found that their energy-harvesting performances are all different from that of the s...