نتایج جستجو برای: tadalafil
تعداد نتایج: 951 فیلتر نتایج به سال:
BACKGROUND/AIM [corrected] During the first 10 years over 50% of diabetes patients develop erectile dysfunction (ED). It is more severe and resistant to therapy than in male patients with normal glucoregulation. The purpose of this pilot study was to estimate the tadalafil (Cialis) efficacy and safety in male patients with diabetes mellitus (DM), together with moderate to severe ED. METHODS T...
Nanocrystals of tadalafil, a poorly water-soluble drug, were successfully prepared by sonoprecipitation technique for improving the solubility and dissolution rate. Tween80 was selected as an efficient surfactant to inhibit aggregation in stabilization of drug nanocrystals. Response surface methodology based on central composite design (CCD) was utilized to evaluate the formulation factors affe...
410. 4 Albersen M, Shindel AW, Mwamukonda KB, Lue TF. The future is today: emerging drugs for the treatment of erectile dysfunction. Expert Opinion Emerg Drugs 2010; 15: 467–80. 5 Albersen M, Shindel AW, Lue TF. Sexual dysfunction in the older man. Reviews in Clinical Gerontology 2009; 19(4): 237–248. 6 Montorsi F, Salonia A, Zanoni M et al. Current status of local penile therapy. Int J Impot R...
Background: This pilot study assessed the efficacy and safety of once-daily tadalafil or tamsulosin versus placebo during 12 weeks in Korean men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Methods: Following a 4-week placebo run-in period, 151 Korean men were randomly assigned to receive once-daily tadalafil 5 mg, tamsulosin 0.2 mg, or placebo for a...
Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious adverse events have been reported in association with PDE5Is. Thrombosis is one of those events, and a few previous reports have suggested the association of PDE5Is with thrombosis. We report...
BACKGROUND Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. METHODS In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Organization functional class II or III symptoms of pulmonary arterial hypertension who had not pre...
the treatment of erectile dysfunction (1). It is a selective, potent and reversible competitive inhibitor of the enzyme phosphodiesterase-5 (PDE5), which causes inactivation of cyclic guanosine monophosphate (cGMP) (2). Due to longer duration of its action (approximately 36 hours) and minimum potential to cause vision abnormalities, tadalafil has gained wide clinical acceptance. However, it has...
Phosphodiesterases (PDEs) are a family of enzymes that hydrolyze cyclic nucleotides, thereby modulating cell functions. Three highly selective PDE5 inhibitors (PDE5i), sildenafil, vardenafil and tadalafil, have been developed for treatment of erectile dysfunction (ED). Experimental evidence showed that chronic treatment with sildenafil PDE5i in a mouse model of diet-induced obesity and insulin ...
Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or ...
A simple, rapid, and sensitive high-performance liquid chromatographic method was developed and validated for determination of tadalafil, a selective and reversible phosphodiesterase inhibitor, in human serum. Methylparaben was used as the internal standard. Optimum conditions for tadalafil assay were investigated. The analyte and internal standard were extracted by a single-step liquid–liquid ...
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