Various solvents can be used in the synthesis of the illicit synthetic drug methylenedioxymethamphetamine (MDMA, commonly known as Ecstasy). In the crystallization process, traces of those solvents can be trapped inside crystals; during the following tabletting process, the solvent traces remain present in the tablets. The forensic investigation of tablets for solvents may increase knowledge of...

In this study, attempts were made to evaluate the effect of various acrylic acid based Carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol HCl, from matrix-type tablets invitro. For this purpose, tablets containing 160 mg of propranolol HCl along with various amounts of Carbopols 934 (C934), 971 (C971), 974 (C974) and Pemulen (Pem) were prepared using the wet gr...

OBJECTIVE To examine the composition of illicitly manufactured "ecstasy" tablets sold on the UK drugs market. METHODS Analysis by gas chromatography of 25 illicit ecstasy tablets handed in under amnesty to Leeds Addiction Unit. RESULTS Illicitly manufactured ecstasy tablets contain a range of ingredients, of widely differing concentrations, and even tablets with the same brand name have var...

A new ecstasy-like substance, meta-chlorophenylpiperazine (mCPP), has been detected in street drugs in the Netherlands. Theoretically, mCPP possesses the potential to become a non-neurotoxic alternative for methylenedioxymethamphetamine (MDMA), the regular psychoactive substance of ecstasy. Since its introduction on the Dutch market of synthetic drugs, the percentage of mCPP-containing tablets ...

The objective of the current study was to determine tablet content and perform dissolution test of expired tablets and tablets which expiry date has not exceeded. The analyzed tablets contained metoprolol tartrate (50 mg) and propranolol hydrochloride (10 mg), respectively. Content determination was performed using spectrophotometric method with UV detection; the percent of dissolved substance ...

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friabi...

Identification of pharmaceutical tablets plays a key role in preventing mix-ups among various types of tablets. Since identification of tablets is most frequently done by imprints, good imprint quality, a property that makes the imprint readable, is of utmost importance. In this paper, we propose a novel method for automated visual inspection of tablets for defect detection and imprint quality ...

PURPOSE To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. METHODS Release and dissolution of crushed amlodipine, atenolol, carbamazepine and warfarin tablets were tested with six foods and drinks that are frequently used in the clinical set...

The mechanical and disintegration properties of paracetamol tablets formulated using Delonix regia seed gum (DRSG) as a binder have been studied in this work. Acacia BP (ACG) and tragacanth BP (TRG) were used as official gum standards. The mechanical properties, i.e. tensile strength (TS) and brittle fracture index (BFI), showed that with an increase in concentration of the gum binder, the tens...

The objective of the present study was to investigate the use of propranolol-magnesium aluminium silicate intercalated complexes as drug reservoirs in hydroxypropylmethylcellulose tablets. The matrix tablets containing the complexes were prepared and characterised with respect to propranolol release and were subsequently compared with those loading propranolol or a propranolol-magnesium alumini...