The interest in the relationship between thyroid dysfunction and obesity is on the increase. This study compares the triiodothyronine-to-thyroxine (T3/T4) ratio in obese and lean children and adolescents, and correlates thyroid hormones with body mass index (BMI) in obese Nigerian children. It is a retrospective study of records of 76 obese children and adolescents with a BMI of 31.7 ± 0.1 kg/m...

Because little has been published on early effects of treatment with amiodarone on thyroid function, we studied serum total and free thyroid hormone, reverse T3, and TSH levels in patients with cardiac arrhythmias during the first 10 days of treatment with a loading dose of amiodarone by iv infusion. Twenty-four patients were enrolled in the study. A standardized loading regimen for the i.v. in...

Oxidized low density lipoproteins (LDL) are highly suspected of initiating the atherosclerosis process. Thyroid hormones and structural analogues have been reported to protect LDL from lipid peroxidation induced by Cu2+ or the free radical generator 2,2'-azobis-'2-amidinopropane' dihydrochloride in vitro. We have examined the effects of thyroid compounds on macrophage-induced LDL oxidation. Hum...

OBJECTIVE To determine the frequency of autoimmune thyroid disease in diagnosed cases of chronic urticaria (CU) and the association between hypothyroidism and chronic urticaria if any. STUDY DESIGN Non-interventional, descriptive study. PLACE AND DURATION OF STUDY Department of Physiology, Dow University of Health Sciences, Karachi, from December 2004 to January 2006. METHODOLOGY The pati...

Thyroid hormone is an important regulator of energy metabolism and crucial for the development of different tissues, in particular the brain (1, 2). Iodine is an essential trace element for the synthesis of thyroid hormone; as their names indicate, the prohormone T4 contains four iodine atoms, and the principal bioactive hormone T3 contains three iodine atoms. If iodine intake is sufficient, th...

INTRODUCTION Hormone replacement therapy (HRT) and walking were investigated independently and in combination, to determine which treatment provided most effect on bone turnover in postmenopausal women. METHODS Using a randomised double-blind pilot study, 10 subjects received HRT (transdermal estradiol, 50 μg/day and oral MPA 5 mg/day) and 12 received placebo for 20 weeks. Following a baselin...

OBJECTIVE The purpose of this study was to assess the systemic effects of low-level laser therapy (LLLT) on thyroid gland function and, consequently, calcium regulation - as measured by serum triiodothyronine (T3), thyroxine (T4), and free calcium levels - when administered after dental implant placement in a rabbit model. BACKGROUND DATA Protocols for the use of laser therapy in several clin...

Thyroid hormone affects the contractile and electrophysiological properties of the cardiac myocyte that result in part from changes in the expression of thyroid hormone-responsive cardiac genes, including those that regulate membrane ion currents. To determine the molecular mechanisms underlying this effect, expression of a voltage-gated K+ channel, Kv1.5, was measured in response to thyroid ho...

Thyroid hormone is one of the critical hormones in mammals and plays an indispensable role in development as well as in lipid and carbohydrate metabolism and energy generation. The thyroid gland secretes mainly L-thyroxine (T4) into the circulation where it is converted to 3,5,3′-triiodothyronine (T3) in liver and kidney. Most of the serum T3 is derived from this conversion, which is catalyzed ...

This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals. Fifty male Wistar rats were randomly assigned to one of the two following groups: control (C; n = 10) and obese (OB; n = 40). The C group received standard food, whereas the OB group was fed a hypercaloric diet for 20 weeks. After this p...