In view of the adverse effects of the administration of pharmacological quantities of iodine to euthyroid patients with a history of a wide variety of thyroid disorders, it has been suggested that iodine-containing medications and radioopaque dyes containing iodine should be avoided, if possible, in patients with underlying thyroid disease. We have now prospectively studied the effects of pharm...

A study of changes in serum T4, T3, and Tg as well as of serum TSH response to TRH was done in ten patients with subacute thyroiditis, from the acute phase up to 56 mo. All patients had symptoms of thyrotoxicosis. The mean +/- s.e.m. serum T4 (21.6 +/- 8.2 micrograms/dl), T3 (315 +/- 191 ng/dl) and Tg (149 +/- 52 ng/ml) concentrations were significantly higher than in normal subjects (8.5 +/- 1...

There have been recent advances in understanding of the local control of thyroid activity and metabolism, including deiodinase activity and thyroid hormone membrane transport. The goal of this review is to increase the understanding of the clinical relevance of cellular deiodinase activity. The physiologic significance of types 1, 2 and 3 deiodinase (D1, D2 and D3, respectively) on the intracel...

New research is demonstrating that thyroid hormone transport across cellular membranes plays an important role in intracellular triiodothyronine (T3) levels of peripheral and pituitary tissues and is proving to have considerable clinical significance. Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide range of common conditions, including insulin resistance, di...

UNLABELLED BACKGROUND Recent attention has been given to subclinical hypothyroidism, defined as an elevation of TSH (4.5-10 uIU/L) with T4 and T3 levels still within the normal range. Controversy exists about the proper lower limit of TSH that defines patients in the subclinical hypothyroidism range and about if/when subclinical hypothyroidism should be treated. Additional data are needed to...

The present study examined the thyroid function and low T3 state in a group of patients exposed to different concentration of fluoride in drinking water. 139 subjects from severe endemic fluorosis areas and 140 subjects as control group were randomly selected. The functional activity of thyroid gland was measured and the findings indicate that the level of TSH and rT3 was significantly (P<0.001...

Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan. A case-control study was conducted at Medani Hospital, Sudan, to investigate thyroid function/antibodies in preeclampsia. The sociodemographic, medical...

Starvation in laboratory rodents results in significant alterations in thyroid hormone economy characterized by decreased circulating levels of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) and a decline in serum thyrotropin (TSH) concentration. To investigate this apparent paradox, we have compared in fasted and hypothyroid animals the intracellular parameters mediating thyroid hormone actio...

Thyroid hormone production is regulated via pituitary thyrotropin (TSH) modulation of thyroxine (T4) prohormone secretion by the thyroid gland and regulation of active triiodothyronine (T3) production in peripheral tissues via metabolic events influencing activities of the iodothyronine monodeiodinase enzyme systems. Control at both levels is developmentally regulated and modified in serious no...

Serum levels of T3, T4, and TSH hormones, some elements, and glucose with regard to their involvement for growth retardation in yearling rams were investigated. A total of 70 yearling rams of the Akkaraman breed, 50 of which were classified with a retarded growth, and the remaining 20 were classified as normal, were included in the study. Serum total T3, total T4, and TSH were measured using ch...