objective(s) the objective of this study was to determine the effect of aqueous extract of origanum vulgare l. ssp. viridis (org) on discrimination learning and long term potentiation (ltp) in ca1 region of the rat hippocampus. materials and methods a group of adult male wistar rats weighing 275±25 g received aqueous extract of org (150, 300, 450 mg/kg/day) by intraperitoneal injection for one ...

Prior studies of head direction (HD) cells indicate strong landmark control over the preferred firing direction of these cells, with few studies exhibiting shifts away from local reference frames over time. We recorded spiking activity of grid and HD cells in the medial entorhinal cortex of rats, testing correlations of local environmental cues with the spatial tuning curves of these cells' fir...

In the present report, rats' performance was assessed in five tasks designed to measure behavioral response to different novel stimuli under different experimental situations. Daily nicotine treatment (0, 0.3 or 1.0 mg / kg) began after the conclusion of the behavioral tasks and continued throughout the experiment. Training of a T-maze visual discrimination task commenced after 11 days of nicot...

This study investigated the effects of repeatedly administration of an aqueous fraction of Paullinia cupana Kunth, Sapindaceae (guaraná) seeds (8 mg/ kg) on rats submitted to the elevated T-maze, model of generalized anxiety and panic disorders. The selective serotonin reuptake inhibitor paroxetine (3 mg/kg), was used as a positive control. To evaluate possible neurotransmissions involvement, i...