نتایج جستجو برای: system biology

تعداد نتایج: 2362616  

2005
Kathy K. Griendling Kathy Griendling

T he renin-angiotensin system is one of the major regulators of blood pressure and fluid and electrolyte homeostasis. Its primary components are 1) angiotensinogen, a large globular protein that serves as the substrate for 2) renin, the enzyme that catalyzes the proteolytic conversion of angiotensinogen to the decapeptide angiotensin I; 3) angiotensin converting enzyme, a dipeptidyl carboxypept...

Journal: :The Yale Journal of Biology and Medicine 1991
Raphael Zahler

This book is easy to read and understand both for the individual with a medical background and the informed layman; I would recommend it to both. It is meant to be read cover to cover, and it would be difficult to skim or browse in selected chapters as the story and its cast of characters unfold chronologically. The work is not meant to be a source book for a current understanding of RMSF, as t...

Journal: :Clinical science 2012
Alex F Chen Dan-Dan Chen Andreas Daiber Frank M Faraci Huige Li Christopher M Rembold Ismail Laher

Most cardiovascular diseases (CVDs), as well as age-related cardiovascular alterations, are accompanied by increases in oxidative stress, usually due to increased generation and/or decreased metabolism of ROS (reactive oxygen species; for example superoxide radicals) and RNS (reactive nitrogen species; for example peroxynitrite). The superoxide anion is generated by several enzymatic reactions,...

Journal: :Endocrine reviews 2012
John R Ussher Daniel J Drucker

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that enhances glucose-stimulated insulin secretion and exerts direct and indirect actions on the cardiovascular system. GLP-1 and its related incretin hormone, glucose-dependent insulinotropic polypeptide, are rapidly inactivated by the enzyme dipeptidyl peptidase 4 (DPP-4), a key determinant of incretin bioactivity. Two classes of medicati...

2004
Wei Tong

Although various genome projects have provided us enormous static sequence information, understanding of the sophisticated biology continues to require integrating the computational modeling, system analysis, technology development for experiments, and quantitative experiments all together to analyze the biology architecture on various levels, which is just the origin of systems biology subject...

2010
Pallavi Penumetcha Kin Lau Xiao Zhu Kelly Davis Todd T. Eckdahl A. Malcolm Campbell

The Escherichia coli lac operon is controlled by a regulatory system that has been the subject of intensive study for the past fi fty years. The system creates metabolic effi ciency by responding to the levels of environmental lactose. In the absence of lactose, the LacI protein acts as a repressor of transcription from the lac promoter. Transcription begins when lactose binds to LacI, which re...

2015
Manuela Monti

We have been recently told by The United Nations Population Division (an international institute that carries out two-yearly assessment of population age-structure, available at: http://www.un.org/en/development/desa/population/theme/ageing/index.shtml) that the demographic structure of the world populations will drastically change by 2050: The rapid ageing of the world population is one of the...

2013
Maria Pia Saccomani

The relevance of model identifiability in system biology is well known. The aim of this paper is to discuss and possibly clarify the role and differences of two different methodologies of testing identifiability of models described by differential equations. One is called structural identifiability and does not require to use data collected in the experiment which, instead, data-based approache...

Journal: :Circulation 1988
V J Dzau D W Burt R E Pratt

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have impo...

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