Evaluation of multicomponent synergy is a critical point in current drug combination studies. However, it is still an ongoing challenge to prioritize the synergistic combination from various pharmacological agents in a high throughput manner. Here we proposed a network target-based approach termed NIMS (Network target-based Identification of Multicomponent Synergy), and showed that NIMS can not...

The goal of this work was to investigate a possible synergistic effect between ethanolic extracts of propolis from Brazil and Bulgaria and some antibiotics (Amoxicillin, Ampicillin and Cefalexin) against Salmonella Typhi. Brazilian and Bulgarian propolis showed an antibacterial action, but the sample from Bulgaria was shown to be more efficient. Both samples showed a similar synergistic effect ...

amitraz is one of the pesticides which is used in a vast area for controlling of the common pistachio psyllid, agonoscena pistaciae (hem.: aphalaridae). in this study the synergistic effect of piperonyl butoxide (pbo) on the toxicity of amitraz on adults of rafsanjan population of common pistachio psyllid was evaluated by residual contact vial (rcv) in laboratory conditions. the results showed ...

conclusions the synergistic effect was found on the healing of infected wounds caused by s. aureus by using an mbp-1 and silver nanoparticles combination in a mouse model. results the mic and mbc of mbp-1 were found to be 0.6 and 0.7 mg/ml, respectively. mic and mbc of silver nanoparticles were determined to be 6.25 and 12.5 mg/l, respectively. mic and mbc of the silver nanoparticles and mbp-1 ...

Objective(s): The significant contribution of nanoparticles to cancer treatment has attracted therapeutic attention. The present study aimed to evaluate the synergistic effects of 5-fluorouracil (5-FU) and zinc oxide nanoparticles (ZnO NPs) as multimodal drug delivery on human breast cancer MCF-7 cells.Materials and Methods: In this in-vitro study, the impact of 5-FU and ZnO NPs in the sin...

Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the ne...

Quantifying cooperation or synergy among random variables in predicting a single target random variable is an important problem in many complex systems. We review three prior information-theoretic measures of synergy and introduce a novel synergy measure defined as the difference between the whole and the union of its parts. We apply all four measures against a suite of binary circuits to demon...

In this paper, we study the performance of a team of classifiers. First, we propose a performance model for a single classifier based on its confusion matrix and prior information. Building upon this model, we propose a supervisor-aided classifier and analyze the performance in comparison to the single classifier. Second, we consider the performance of a team of two classifiers. Since the decis...

Multimodal interface aims at overcoming the shortcomings of conventional human-computer communication -serialized input, excessive accuracy, and low input efficiency -by exploiting the complementary nature of multiple modalities in interpreting user intent, thus improving the efficiency and naturalness of humancomputer interaction. In this paper, we present motivations driving multimodal interf...