Timely diagnosis of hyponatremia is important for preventing potential morbidity and mortality as it is often an indicator of underlying disease. The most common cause of eurvolemic hyponatremia is the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Recent studies have demonstrated that proinflammatory cytokines such as interleukin (IL) 1β and IL-6 are involved in the developm...

The distribution of neuromyelitis optica (NMO)-characteristic brain lesions corresponds to sites of high aquaporin-4 (AQP4) expression, and the brainstem and hypothalamus lesions that express high levels of AQP4 protein are relatively characteristic of NMO. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the important causes of hyponatremia and results from an abn...

Four cases with inappropriate antidiuretic bormone syndrome d t e d with carcinoma of the long are repofled. It is mnchded th.1 certnin tumors manif& a cnpnbilily to synthesize and release a substance s i m i i to antidiuretic bormoue which enhances mter reabsorption, leading to dllntion and expmndon d the eshacellolnr Ouid volume. These changes in the extrncellolsr fluid volnme stimulate the t...

In the neurocritical care setting, hyponatremia is the commonest electrolyte disorder, which is associated with significant morbimortality. Cerebral salt wasting and syndrome of inappropriate antidiuretic hormone have been classically described as the 2 most frequent entities responsible of hyponatremia in neurocritical care patients. Nevertheless, to distinguish between both syndromes is usual...

Syndrome of inappropriate antidiuretic hormone (SIADH) secretion is an endocrinological disorder which occurs when there evidence continued (ADH) in the absence appropriate osmotic volume stimulus. Most commonly it caused by different types cancer or medications (eg. diuretics, antidepressants, antipsychotics...). Secondary adrenal insufficiency insufficient adrenocorticotropic (ACTH) and corti...