The objective of the present work was to develop stomach specific delivery systems for am xicillin and metronidazole using chitosan and poly(acrylic acid) hydrogels. Chitosan and poly(acrylic acid) hydrogels were prepared with different composition of copolymers. The hydrogels were evaluated for swelling studies, mucoadhesive studies, in vitro drug release, scanning electron microscopic and FTI...

Amphibians are suffering unprecedented global declines. A leading cause is the infectious disease chytridiomycosis caused by the chytrid fungus Batrachochytrium dendrobatidis. Chytridiomycosis is a skin disease which disrupts transport of essential ions leading to death. Soluble factors produced by B. dendrobatidis impair amphibian and mammalian lymphocytes in vitro, but previous studies have n...

Previous studies have shown that human myocardium loses its ability to swell at pH 11.2 with increasing age. This investigation indicated that the age-related difference does not exist at the subccllular level or after treatment with collagenase. Swelling did not correlate well with myofiber size or acid and base binding capacity. It was concluded that the increased rigidity with age is due to ...

The purpose of this study is to develop novel intestinal-specific drug delivery systems with pH sensitive swelling and drug release properties. Methacrylic-type polymeric prodrugs were synthesized by free radical copolymerization of methacrylic acid, poly(ethyleneglycol monomethyl ether methacrylate) and a methacrylic derivative of N-(4-hydroxyphenyl)-2-(4-methoxyphenyl) acetamide in the presen...

The maintenance of furnaces is one the most important problems for by-product coke production. Swelling pressure least studied factors affecting lining furnace walls. results studies swelling PJSC “Koks” feedstock coal are presented in this paper. Research has been carried out to identify dependence on quality indicators, estimated during incoming control central plant laboratory “Koks”. plasti...

This article is also accessible online at: http://BioMedNet.com/karger Dear Sir, A recent study of corneal swelling by Aakre and Doughty [1] found two regimes in the time course of tissue fluid imbibition. We are pleased to note that this confirms our discovery made over 10 years ago at the University of New South Wales, Sydney [2, 3]. We first reported these results in 1986–1988 to meetings of...

A novel polypeptide hydrogel has been synthesized by crosslinking poly(L-glutamic acid) (PLG) with poly(ethylene glycol) (PEG). The PLG-PEG hydrogel was shown to be highly hydrophilic, and the extent of swelling varied with pH, increasing at higher ionization of the PLG. Aside from electrostatic effects, such as ion-ion repulsion and internal ion osmotic pressure, circular dichroism studies sho...