BACKGROUND Understanding the excretion of 3,4-methylenedioxymethamphetamine (MDMA) and metabolites in sweat is vital for interpretation of sweat tests in drug treatment, criminal justice, and workplace programs. METHODS Placebo, low (1.0 mg/kg), and high (1.6 mg/kg) doses of oral MDMA were given double-blind in random order to healthy volunteers (n = 15) with histories of MDMA use. Participan...

Objectives Recent sweat chloride guidelines published by the Cystic Fibrosis Foundation changed the intermediate sweat chloride concentration range from 40-59 mmol/L to 30-59 mmol/L for age > 6 months. We wanted to know how this new guideline would impact detection of cystic fibrosis among patients who previously had sweat tests done at Texas Children's Hospital. Methods We revisited sweat ch...

Two different and interrelated steps are involved in the assessment of active sweat glands: stimulation of sweating and its subsequent recording and quantification. Sweat activation has been promoted by simple thermal stimulation, by intradermal injection of drugs such as methylcholine, and by dermal introduction of such drugs using iontophoresis. Gibson and Cooke’s device for iontophoresis, on...

BACKGROUND The classic sweat test (CST) is the golden standard for cystic fibrosis (CF) diagnosis. Then, our aim was compare the production and volume of sweat, and side effects caused by pulsed direct current (PDC) and constant direct current (CDC). To determine the optimal stimulation time (ST) for the sweat collection. To verify the PDC as CF diagnosis option. METHODS Prospective study wit...

a case of pleomorphic adenoma in sweat gland is reported here. the histopathologic report confirmed the diagnosis. pleomorphic adenoma is most common in salivary glands but very rare in sweat glands. pleomorphic adenoma in sweat gland and the similar tumors of eccring sweat gland are described that bear a striking resemblance to pleomorphic adenomas of salivary gland. upon closer examination, t...

Introduction 1 Types of Exocrine Sweat Glands 2 Structure of the Eccrine Sweat Gland 2 Secretory Coil 2 Reabsorptive Sweat Duct 2 Sympathetic Nervous System Control of Sweating 3 Substances Used To Determine Sweat Gland Function In Vitro 3 Formation of Primary Sweat 4 Calcium Mobilisation Mediators 4 Effect of Increased Intracellular Calcium on Sweat Secretion 5 Other Biochemical Requirements f...

Several reports have demonstrated that sweat is a suitable alternative biological matrix for monitoring recent drug use (1, 2). This is based on the assumption that, in the context of the absorption/distribution/metabolism/excretion (ADME) cycle of drugs, a small but sufficient fraction of a drug is excreted in sweat and can be tested. The passage of lipid-soluble compounds from blood to other ...

Methods Healthy men and women ages 19-30 who self-reported 150-450 minutes of aerobic exercise per week were recruited at two different laboratories (n= 48; n= 40). All participants were provided with the same three meals and beverages to consume in the 24 hours before each exercise session. Participants consumed one test beverage, while exercising, during each visit including water, a caloric ...