The most popular and patient-friendly method of drug administration is often thought to be the oral route administration. Compared conventional release formulations, advancements in formulation technology, including modified dosage forms or sustained forms, have been extensively accepted. A form provides a prolonged over an extended period, thereby giving better patient compliance enhanced bioa...

Objective(s): The present study aimed to fabricate chitosan/polyethylene oxide (CS/PEO) electrospun nanofibers loaded with Aloe vera extract for biomedical applications. The polymer-to-extract ratio and electrospinning parameters (applied voltage and nozzle-to-collector distance) were evaluated in order to optimize the process of nanofiber fabrication. Materials and Methods: The character...

Background & Aims: The topical anesthetic effects of diphenhydramine combined with ingredients such as aluminum and magnesium hydroxide have been used for many years in modern medicine. Due to the limited durability of anesthetic mouthwashes due to saliva secretion and the spreading use of herbal and natural medicines in pharmacotherapy, this study was designed to formulate diphenhydramine in t...

The effect of ionic and non-ionic excipients and additives as modulators of swelling and erosion kinetics and verapamil HCl release from guar-based matrix tablets was investigated. Tablet dissolution, erosion and water uptake studies were carried out using a modified USP 23 Apparatus 2 method. The kinetics of gel strength and texture development were studied by textural analysis. Near linear dr...

the aim of this study was to develop a derivative of chitosan as pharmaceutical excipient used in sustained-release matrix tablets of poorly soluble drugs. a water-soluble quaternary ammonium carboxymethylchitosan was synthesized by a two-step reaction with carboxymethylchitosan (cmcts), decylalkyl dimethyl ammonium and epichlorohydrin. the elemental analysis showed that the target product with...

The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate water insoluble drugs a simplistic approach. However, there is no current study on sustained-release formulation using technology. In this study, an attempt was made to produce Liqui-Tablet for first time matrix-based non-volatile co-solvent used investigatio...

Abstract: Aim: To develop hydrogel films for hydrophilic drug delivery with citric acid-cross-linked Hydroxypropyl Methylcellulose (HPMC) and (MC). Materials Methods: The existing study is concerned the development of HPMC/MC employing acid as a cross-linking agent in order to accomplish loading while simultaneously releasing drugs (ciprofloxacin hydrochloride). Thermal analysis ATR-FTIR spectr...

Our previous work on Drosophila synapses has suggested that two vesicle populations possessing different recycling pathways, a fast pathway emanating from the active zone and a slower pathway emanating from sites away from the active zone, exist in the terminal. The difference in recycling time between these two pathways has allowed us to create a synapse that possesses the small, active zone s...