Whether morning blood pressure surge influences the molecular mechanisms of plaque progression toward instability is not known. Recently, we have demonstrated enhanced activity of the ubiquitin-proteasome system in human plaques and evidenced that it is associated with inflammatory-induced plaque rupture. We evaluated the inflammatory infiltration and ubiquitin-proteasome activity in asymptomat...

The impact of the surge tank has been incorporated into the platform of the impulse response method. The impedance functions for pipeline systems equipped with a surge tank were also derived. Hydraulic transients could be efficiently analyzed by the developed method. The simulation of normalized pressure variation using the method of characteristics and the impulse response method shows good ag...

BACKGROUND The morning surge of blood pressure (BP) is associated with alpha-adrenergic activity. We studied the association between the alpha-adrenergic morning surge in BP and silent cerebrovascular disease in elderly patients with hypertension. METHODS We conducted ambulatory BP monitoring three times (twice at baseline and after nighttime dosing of the alpha1-blocker doxazosin) in 98 elde...

Morning blood pressure (BP) surge is considered to be an independent risk factor for cardiovascular diseases. We tested the hypothesis that increased large-artery stiffness and impaired sympathetic baroreflex sensitivity (BRS) contribute to augmented morning surge in elderly hypertensive subjects. Morning surge was assessed as morning systolic BP averaged for 2 h just after waking up minus mini...

Background: To study the effectiveness of Clomiphene citrate (CC) in preventing a premature LH surge during controlled ovarian stimulation in women undergoing assisted reproduction. Materials and Methods: Couples were randomized to receive human menopausal gonadotrophins (hMG) followed by CC or hMG alone till the day of hCG. The primary outcomes were the incidence of a clinical pregnancy and pr...

Gulf surges are transient disturbances that propagate along the Gulf of California (GoC) from south to north, transporting cool moist air toward the deserts of northwest Mexico and the southwest United States during the North Americanmonsoon. They have been shown to modulate precipitation and have been linked to severe weather and flooding in northern Mexico and the southwest United States. The...

INTRODUCTION Poison Control Centers (PCCs) play an integral role in the preparation for and management of poison emergencies. Large-scale public health disasters, caused by both natural and human factors, may result in a drastic increase in the number of inquiries received and handled by PCCs in short periods of time. In order to plan and prepare for such public health emergencies, it is import...

A major challenge in embryology is to understand how cells become specialized into distinct lineages and assembled into a pattern of tissues that will make up the embryo. The discovery that patterns of gene expression are conserved among embryos of the favourite vertebrate species for laboratory study — zebrafish, frog (Xenopus), chick and mouse — has led to a surge of interest in finding out h...