PURPOSE The aim of our study was to investigate whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows visualization of changes in microcirculation between healthy controls on the one side and early/advanced stages of plasma cell disease on the other. EXPERIMENTAL DESIGN We examined a group of 222 individuals consisting of 60 patients with monoclonal gammopathy of undet...

Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell neoplasia, characterized by monoclonal plasma cell proliferation in the absence of end-organ damage, but with a high risk of progression to multiple myeloma. It has therefore to be distinguished from monoclonal gammapathy of undetermined significance (MGUS), which has a much lower risk of progression, but also from multiple myelom...

Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder defined in 1980 by Kyle and Greipp on the basis of a series of six patients who met the criteria for multiple myeloma (MM) but whose disease did not have an aggressive course [1]. At the end of 2014, the International Myeloma Working Group (IMWG) updated the definition, and SMM is now defined as a plasma cell disorder cha...

A macroscopic traffic flow model, called the switchingmode model (SMM), has been derived from the cell transmission model (CTM) and then applied to the estimation of traffic densities at unmonitored locations along a highway. The SMM is a hybrid system that switches among different sets of linear difference equations, or modes, depending on the mainline boundary data and the congestion status o...

The adsorption thermodynamics of copolymers, based on ethylene oxide (EO) and propylene oxide (PO) units, at the laponite (RD) clay/liquid interface was determined at 298 K. The copolymer nature was tuned at molecular level by changing the hydrophilicity, the architecture and the molecular weight (Mw) keeping constant the EO/PO ratio. Polyethylene (PEGs) and polypropylene (PPGs) glycols with va...

An approximate method is evaluated for calculating the second virial coefficient in a dilute macromolecular solution bounded by two interfaces. The approximation is essentially the superposition of the coefficients calculated independently for each surface. To test this approach, the depletion interaction between two particles in a solution of nonadsorbing, spherical macromolecules is calculate...

We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (CB2) receptors using 2-week daily administration of the CB2 inverse agonist SMM-189. CB2 in...

The metabolic effects of inhibitors of two enzymes in the pathway for biosynthesis of branched-chain amino acids were examined in Salmonella typhimurium mutant strain TV105, expressing a single isozyme of acetohydroxy acid synthase (AHAS), AHAS isozyme II. One inhibitor was the sulfonylurea herbicide sulfometuron methyl (SMM), which inhibits this isozyme and AHAS of other organisms, and the oth...

Single-molecule magnets (SMMs) hold promise for unmatched information storage density as well applications in quantum computing and spintronics. To date, the most successful SMMs have been organometallic lanthanide complexes. However, their surface immobilization, one of requirements device fabrication commercial application, remains challenging due to sensitivity magnetic properties small chan...