The past decades have seen a rise in the prescription of antipsychotic drugs European population, despite risk extra-pyramidal, metabolic and cardiac side effects. A multi-analyte liquid chromatography – triple quadrupole mass spectrometry method was developed for quantification 38 plasma. Samples were extracted by straightforward liquid–liquid extraction with methyl-tertiary-butyl-ether compou...

BACKGROUND Enoxaparin dosage for obese patients and patients with renal impairment remains controversial. OBJECTIVE To compare anti-factor Xa activity (anti-Xa) among obese and renal impairment patients to patients with healthy weight and adequate renal function. DESIGN Open, prospective, nonrandomized clinical trial. SETTING A major community teaching hospital. PATIENTS A total of 233 ...

BACKGROUND Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates its use in preventing rejection after kidney transplantation. This variability might be caused by genetic polymorphisms in metabolizing enzymes. METHODS We used TaqMan analyses to evaluate the impact of a newly discovered CYP3A4 (cytochrome...

This study aims to test the hypothesis that thiazolidinedione rosiglitazone (RSG), a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist, causes cardiotoxicity independently of PPARγ. Energy metabolism and mitochondrial function were measured in perfused hearts isolated from C57BL/6, cardiomyocyte-specific PPARγ-deficient mice, and their littermates. Cardiac function and mito...

Dieulafoy's lesions are a rare cause of gastrointestinal hemorrhage. Extragastric Dieulafoy's lesions are even more uncommon. We report the case of a 75-year-old woman who presented with gastrointestinal bleeding from a transverse colonic Dieulafoy's lesion. She presented with two episodes of melena followed by one episode of fresh blood per rectum. In addition, there was associated presyncope ...

Firstly, the 250-mg/kg dose of rectal paracetamol, which was divided into three doses per day for 3 days (each dose equivalent to 27 mg/kg) were overdoses, because the recommended dose is 10 to 15 mg/kg. However, the authors failed to pinpoint this, and instead focused on the daily dose, which in fact was only at the upper limit of the recommended daily dose. The Pediatric Dosage Handbook recom...