PURPOSE Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed RESULTS To improve understanding of transscleral drug delivery to the posterior segme...

PURPOSE To describe the clinical characteristics, management and treatment outcomes of patients with post-surgical suprachoroidal hemorrhage (SCH). METHODS A retrospective cross-sectional study was conducted, in which the medical records of 9 consecutive patients with SCH admitted to the Goldschleger Eye Institute were reviewed. RESULTS The mean age was 74 years (range 61-84) and the mean f...

INTRODUCTION Massive suprachoroidal hemorrhage (SCH) that completely fills the vitreous cavity rarely resolves spontaneously. Even in cases with spontaneous resolution, long-term visual prognosis is disappointing due to retinal detachment or deterioration of preexisting ocular diseases. To the best of our knowledge, the first case of spontaneous resolution of massive SCH is reported with good l...

PURPOSE Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug delivery system in the rat model of endotoxin-induced uveitis (EIU). METHO...

Purpose To report the early results of suprachoroidal silicone implant surgery in intractable glaucoma. Materials and methods A modified silicone implant with no valve was implanted into the suprachoroidal space of 15 eyes with intractable glaucoma. Results The mean age of the patients was 53.0 ± 24.5 (range 7–85) years, the mean follow-up time was 17.1 ± 4.8 (range 10–28) months, and the mean ...

horoidal effusion—an abnormal accumulation of fluid in the suprachoroidal space—is a common complication of glaucoma surgery. However, this may arise from other intraocular surgeries and a number of conditions, including inflammatory and infectious diseases, trauma, neoplasms, drug reactions, and venous congestion. Idiopathic causes fall under the umbrella of uveal effusion syndrome, a rare con...

BACKGROUND The current method of delivering gene replacement to the posterior segment of the eye involves a three-port pars plana vitrectomy followed by injection of the agent through a 37-gauge cannula, which is potentially wrought with retinal complications. In this paper we investigate the safety and efficacy of delivering adeno-associated viral (AAV) vector to the suprachoroidal space using...

Background: The aim of this work was to study the clinical outcomes, operative time, and complications 27-gauge (27G) microincision vitrectomy surgery in posterior segment eye disease (PSED). Material methods: This prospective observational conducted at a tertiary care hospital Kashmir, India. 27G transconjunctival sutureless performed on 101 eyes patients with PSED. Results: Of patients, pars ...