Domperidone is practically insoluble prokinetic drug; the systemic bioavailability of the drug following oral administration is only 13-17% because of extensive presystemic metabolism in the gut wall and liver. The applicability of the solid dispersion technique as a method for enhancing absorption of the drug through achieving better dissolution characteristics and better bioavailability for d...

Terconazole is a new, broad-spectrum, triazole antifungal agent. The aim of this study was to compare the efficacy and safety of a 6-day course of a terconazole vaginal suppository (80 mg) with two doses of oral fluconazole (150 mg) for the treatment of severe vulvovaginal candidiasis (SVVC). In this prospective, randomized case-control study, 140 consecutive patients with SVVC were enrolled at...

OBJECTIVE This study was conducted to estimate the incidence and clinical predictors of post-thoracotomy shoulder pain and to determine the effectiveness of thoracic epidural block in alleviating this pain. DESIGN A prospective clinical trial. SETTING University teaching hospital. PARTICIPANTS AND INTERVENTIONS Thirty-two adult patients undergoing elective thoracic surgery consented to pa...

BACKGROUND Ulcerative proctitis (UP) usually presents as fresh rectal bleeding. Successful treatment using topical mesalamine 5-aminosalicyclic acid (5-ASA) 500 mg BID suppository led to developing a once-a-day formulation that could contribute to better acceptability and ease of use by patients. The objective of this randomized trial, conducted in 18 centers, was to compare efficacy of 2 modes...

Let be a compactly supported positive measure on the real line, with associated Christo¤el functions n (d ; ). Let g be a measurable function that is bounded above and below by positive constants on supp[ ] . We show that if g is continuous on some compact set J , then for a.e. x 2 J , we have