within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. this has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (cscs), has the capacity to self-renew and form new tumors . it has been proposed that the development of tumors is based exclusiv...

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the study determined optimum inventory levels for various bakery resources using the bread supply chain network in onitsha city. structured questionnaires were administered among bakery factories. the optimum design achieved through the optimization model was compared with the existing systems. analysis of 90 bakeries with a combined capacity of 3960 revealed that total money n 564,408,477.28 i...

Maternal hypoxia is associated with a decrease in left ventricular capillary density while cardiac performance is preserved, implying a mismatch between metabolism and diffusive exchange. We hypothesised this requires a switch in substrate metabolism to maximise efficiency of ATP production from limited oxygen availability. Rat pups from pregnant females exposed to hypoxia (FIO2=0.12) at days 1...

Reactive power compensation is an important challenge in current and future smart power systems. However, in the context of reactive power compensation, most existing studies assume that customers can assess their compensation value, i.e., Var unit, objectively. In this paper, customers are assumed to make decisions that pertain to reactive power coordination. In consequence, the way in which t...

Knudson's carcinogenic model, which simulates incidence rates for retinoblastoma, provides compelling evidence for a two-stage mutational process. However, for more complex cancers, existing multistage models are less convincing. To fill this gap, I hypothesize that neoplasms preferentially arise when stem cell exhaustion creates a short supply of progenitor cells at ages of high proliferative ...

Poor rural households in Malawi often chose to supplement their income through additional casual work on other farms (“ganyu” labor). Based on data from the Second Integrated Household Survey for 2004, we explore the potential objectives and determinants of ganyu supply. We find a confirmation of the neoclassical theoretical hypothesis whereby households use ganyu as a consumption smoothing opt...

In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin fam...