We studied the role of prostaglandins and free radicals in the induction of the functional and morphological pial arteriolar abnormalities produced by concussive brain injury. Anesthetized cats equipped with a cranial window for the observation of the pial microcirculation were subjected to concussive brain injury using a fluid-percussion device following administration of cyclooxygenase inhibi...

Iron chlorin e6 (FeCe6) has recently been proposed to be potentially antimutagenic and antioxidative. However, the antioxidant property of FeCe6 has not been elucidated in detail. In this study, we investigated the ability of FeCe6 to scavenge hydroxyl radical and to protect biomolecules and mammalian cells from oxidative stress-mediated damage. In electron spin resonance (ESR) experiments, FeC...

There is now compelling evidence that the L-arginine/nitric oxide (NO) pathway generates the non-adrenergic non-cholinergic (NANC) neurotransmitter which mediates smooth muscle relaxation in a variety of nitrergically-innervated tissues. However, one strange aspect of this nitrergic neurotransmission process is that certain drugs (i.e. superoxide generators and NO-scavengers) powerfully inhibit...

Human monocytes stimulated with phorbol myristate acetate were able to rapidly destroy autologous erythrocte targets. Monocyte-mediated cytotoxicity was related to phorbol myristate acetate concentration and monocyte number. Purified preparations of lymphocytes were incapable of mediating erytlrocyte lysis in this system. The ability of phorbol myristate acetate-stimulated monocytes to lyse ery...

Previous experiments have shown that, following experimental fluid-percussion brain injury, cyclo-oxygenase-dependent formation of oxygen radicals prevents arteriolar vasoconstriction in response to hyperventilation. The oxygen radical scavengers superoxide dismutase and catalase restore normal reactivity; however, they are not routinely available for clinical use. The present study tested whet...