Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...

Aromatic rings form energetically favorable interactions with many polar groups in chemical and biological systems. Recent molecular studies have shown that sulfonamides can chelate metal ions hydrogen bonds, however, it is presently not established whether the sulfonamide functionality also interacts aromatic rings. Here, synthetic, spectroscopic, structural, quantum analyses on 2,6-diarylbenz...

Phenazopyridine, at its maximum tolerated dose, did not affect the effectiveness of sulfonamides against uropathogenic bacterial species in mice.

In October 1955 three reports in the Deutsche Medizinische Wochenschrift' described a new sulfonamide derivative possessing the ability when given by mouth to reduce normal blood sugar values to subnormal, and elevated blood and urine sugar values in diabetes to normal. Reduction of normoglycemia had been shown with other sulfonamide derivatives as early as 1942," but the application to therapy...

The sulfonamides and their structurally related derivatives, such as the sulfamates and sulfamides, possess the general formula A-SO2NHR, in which the functional group is either directly bound to an aromatic, heterocyclic, aliphatic, or sugar scaffold (of type A), or appended to such a scaffold via a heteroatom, most frequently oxygen or nitrogen (leading thus to sulfamates and sulfamides, resp...

Purpose Up to 90% of antibiotics that are fed to livestock are excreted unaltered or as metabolites and thus are present in manure. By application of manure as fertilizer, veterinary antibiotics can reach soil and groundwater. The aim of this study is to determine the effect of three commonly used (and simultaneously applied) sulfonamide antibiotics on both function and structural diversity of ...