Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.

In contrast to prior experience in northeastern Brazil, three of four Shigella flexneri strains recently isolated from patients with acute inflammatory diarrhea in this setting were found to be resistant to sulfamethoxazole-trimethoprim. The resistant strains contained large, different plasmids, two of which were transferred with sulfamethoxazole-trimethoprim resistance to Escherichia coli K-12...

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

Broiler breeder farms could be a reservoir of Escherichia coli, disseminating antimicrobial resistance and virulence factors. We investigated the E. coli from nine broiler characterised their genes. A total 256 showed high level to tetracycline, nalidixic acid, ampicillin, cephalothin, followed by trimethoprim–sulfamethoxazole chloramphenicol. The trimethoprim–sulfamethoxazole, chloramphenicol ...

Sulfamethoxazole is a widely—used antibiotic with high water solubility and low biodegradability, which was considered refractory environmental pollutant. Hence, series of functionalized hybrids uniting Cu3P TiN were prepared. The Cu3P/TiN—x composites remarkably removed the sulfamethoxazole in solution compared alone. All as—prepared integrated advantages strong adsorption photocatalysis achie...

Ciprofloxacin and sulfamethoxazole are two antibiotics commonly detected in the aquatic environment, but information on their toxicity towards natural microbial communities is largely absent. In particular no data are available for marine microorganisms. The aim of the current study was therefore to evaluate the chronic toxicity of ciprofloxacin and sulfamethoxazole to natural marine biofilms (...

Infectious agents cause disease in virtually any susceptible hosts. In the poultry production and medicine, pathogens were eliminated from a line of a breeder by injection of antibiotics into hatching eggs. There is little information available describing the safety of the folate antimetabolite/sulfonamide class of antibiotics on the game birds embryonated eggs. The objective of this study was ...

The activity of Ro 15-8074/001 was compared with that of cefaclor, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, norfloxacin, and ceftriaxone against 225 clinical isolates. It was more active than cefaclor, amoxicillin-clavulanic acid, and trimethoprim-sulfamethoxazole against members of the family Enterobacteriaceae and Haemophilus influenzae and had activity similar to that of c...