Three novel pyrazolo[3,4-b]pyridines were synthesized via the cyclization of 5-amino-1-phenylpyrazole with corresponding unsaturated ketone in catalytic presence ZrCl4. The ketones afforded by modifying a stabilized ylide facilitated Wittig reaction fairly high yields. compounds exhibited exciting photophysical properties dimethylamine phenyl-bearing pyrazolopyridine showing exceptionally large...

The cover picture shows a convenient microwave-assisted CH activation for the preparation of several phenoxythieno[3,2-b]pyridines. main challenge CH-activation is control regioselectivity with heterocyclic substrates containing multiple C−H bonds that may have similar reactivities. For these reasons and on basis our previous work, we present in this article simple approach to access, very effi...

Abstract Pyrazolo[3,4-b]pyridine is a privileged scaffold found in many small drug molecules that possess wide range of pharmacological properties. Efforts to further develop and exploit synthetic methodologies permit the functionalization this heterocyclic moiety warrant investigation. To end, series novel 1,3-disubstituted pyrazolo[3,4-b]pyridine-3-carboxamide derivatives have been prepared b...

Effects of imidazoles and substituted pyridines and pure s-donors on the oxidation of cyclooctene with NaIO4 by 5,10,15,20-tetraphenylporphyrinato-manganese(III) acetate, Mn(TPP)OAc, and 5,10,15,20-Tetramesitylporphyrinato-manganese(III) acetate, Mn(TMP)OAc, catalysts in CH2Cl2-H2O solvent are studied. Coordination of the nitrogen donors to the Mn...

Iodination of carbohydrate-derived 3,6-dihydro-2H-1,2-oxazines of type 3 using iodine and pyridine in DMF furnished 5-iodo-substituted 1,2-oxazine derivatives 4 with high efficacy. The alkenyl iodide moiety of 1,2-oxazine derivatives syn-4 and anti-4 was subsequently exploited for the introduction of new functionalities at the C-5 position by applying palladium-catalyzed carbon-carbon bond-form...