Fusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized: (1) benzo-α-pyrone commomly called coumarins and (2) benzo-Υ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerable att...

1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are both theoretical and practical interest. This class has been known for about 100 years, in recent decades have become one the most attractive objects research chemistry due their unique properties. Recently, considerable number innovative synthesis methods developed interesting modification chemical variations propo...

BACKGROUND The benefit and risk of oral anticoagulation in dialysis patients are debated controversially. METHODS We prospectively followed 235 dialysis patients of the INVOR Study (Study of Incident Dialysis Patients in Vorarlberg) for up to 7 years and analysed the prevalence and incidence of atrial fibrillation (AF) and the impact of coumarin therapy on survival. Oral anticoagulation was m...

3-[(2'-Substituted benzylidene amino thiazol-4'-yl) amino] coumarins (5a-5d) and 3-[(2'-Substitutd benzylidine amino oxazole-4'-yl) amino coumarins (8a-8d) were prepared by the reaction with compounds 4 and 7 respectively with various substituted aldehydes in the presence of glacial acetic acid. All the synthesized compounds 120 have been screened for their antibacterial and antifungal activiti...

The Authors have studied the capacity to photoreact with native DNA and r-RNA using six coumarins and four 4',5'-dihydro-furo-coumarins. Six of these substances have shown a definite photoreactivity both with DNA and r-RNA, even if in a very much lower extent in respect to that of skin-photosensitizing furocoumarins. The low capacity to photoreact with nucleic acids of these substances is discu...