BACKGROUND/PURPOSE One of the most common complications of the peritoneal dialysis (PD) is the infection of the exit site of the peritoneal catheter. The aim of the present study was to evaluate the efficacy of the subcutaneous gentamicin injection around the cuff as a part of routine treatment of the resistant exit site infection (ESI). METHODS If the exit site remains infected after a 2-wee...

BACKGROUND Mild to moderate musculoskeletal trauma is a common cause for an emergency room visit, and frequent pain is one of the cardinal symptoms of consultation. The objective of this study is to assess the perception of a single subcutaneous dose of 50 mg tramadol for pain management in patients with mild to moderate musculoskeletal trauma, likewise to appraise the perception of pain by sub...

AIMS/INTRODUCTION In previous studies, hydrogen gas (H2) administration has clearly shown effectiveness in inhibiting diabetes. Here, we evaluated whether subcutaneous injection of H2 shows enhanced efficacy against type 2 diabetes mellitus induced in mice by a high-fat diet and low-dose streptozotocin treatment. MATERIAL AND METHODS H2 was injected subcutaneously at a dose of 1 mL/mouse/week...

We have already reported 1 the results of our studies with subcutaneous injections of immune serum in spirocha~tosis icteroh~emorrhagica. In the present article are presented the results of injections made by the intravenous method, which has in the main been employed in the serotherapy of Weil's disease since May, 1916. The number of patients treated in this manner in our clinic from May, 1916...

In previous studies, we have demonstrated that the low molecular weight protein lysozyme can be used as a renal-selective drug carrier for delivery of the angiotensin-converting enzyme (ACE) inhibitor captopril. Typically, such macromolecular drug-targeting preparations are administered intravenously. In the present study, we investigated the fate of captopril-lysozyme following subcutaneous ad...

background and aims. statins, the mevalonate pathway inhibitors, have effects on bone formation in vitro and in vivo. the aim of the present study was to investigate whether injection of statins could lead to ectopic bone formation in rats. materials and methods. a single dose (0.5 mg) of simvastatin, atrovastatin, lovastatin and polyethylene glycol (control material) were injected into four qu...

Abstract Objective To determine and compare the abilities of ShotBlocker cryotherapy for reducing pain anxiety associated with subcutaneous injections. Subcutaneous injection has been used excessively continuous, low-dose administration drugs. Considering that these drugs may require prolonged administration, new devices methods are needed to decrease repeated drug Methods A quasi-experimental ...

OBJECTIVE To compare the dose-response relationship following inhalation of regular insulin delivered via the Aerodose insulin inhaler with that following subcutaneously injected regular insulin in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty-four patients with type 2 diabetes (21 nonsmoking men, aged 36-80 years) each received two of three doses of 80, 160, or 240 units ...

Experiments were carried out with Sw albino mice and it was concluded that the percutaneous route via abdominal skin was significatively more efficient than tail immersion method and subcutaneous infection; the subcutaneous injection was significatively more efficient than the percutaneous infection through the tail; this latter and the intraperitoneal injection, resulted in similar infections,...