نتایج جستجو برای: subcutaneous allergen immunotherapy

تعداد نتایج: 78888  

Journal: :European Annals of Allergy and Clinical Immunology 2020

2013
Annemie Narkus Ulrike Lehnigk Dietrich Haefner Regine Klinger Oliver Pfaar Margitta Worm

BACKGROUND Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study was performed to examine the placebo response in SIT trials that employed a ba...

2009
Corinne A. Keet

REVIEWERS COMMENTS. Although it is not commercially available in the United States, SLIT for pollen allergy has gained widespread acceptance in Europe, and evidence supporting its safety and efficacy is accumulating. The promise of SLIT is that it might provide a safer and more-convenient alternative to subcutaneous immunotherapy while maintaining efficacy. Much of the literature supporting its...

2017
Have Aliu Carola Rask Jens Brimnes Thomas Lars Andresen

Immunotherapy by sublingual administration of allergens provides high patient compliance and has emerged as an alternative to subcutaneous immunotherapy for the treatment of IgE-associated allergic diseases. However, sublingual immunotherapy (SLIT) can cause adverse events. Development of allergen delivery systems enabling more efficient delivery and hence lower allergen load might reduce the a...

Journal: :Allergy 2012
M Calderón V Cardona P Demoly

Allergen immunotherapy was introduced by Leonard Noon 100 years ago and is the only disease-modifying treatment for allergic individuals. Improved understanding of immunology has taught us a great deal about the underlying mechanisms involved in allergen immunotherapy; however, despite these developments, a number of important questions remain unanswered. Several of these questions relate to th...

Journal: :Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2008
Jitka Pokladnikova Irena Krcmova Jiri Vlcek

BACKGROUND Sublingual allergen immunotherapy (SLIT) is a commonly used alternative route of administration to standard subcutaneous immunotherapy (SCIT) in Europe. Despite its wide use, the cost-effectiveness of SLIT vs SCIT has not been well established. OBJECTIVE To evaluate the cost and effectiveness of SLIT compared with SCIT in patients with allergic rhinoconjunctivitis during a 3-year s...

2011
Anna Nowak-Wegrzyn

Diverse therapeutic strategies for food allergy are under investigation including food allergen-specific and nonspecific approaches. Allergen-specific approaches include immunotherapy with native food allergens, immunotherapy with mutated recombinant allergens, and diets containing extensively heated milk or egg. Native allergen immunotherapy can be administered via oral, sublingual, subcutaneo...

Journal: :American journal of otolaryngology 2009
Sarah K Wise Jamie Woody Sarah Koepp Rodney J Schlosser

PURPOSE Immunotherapy is the titrated exposure of allergens to induce immunologic tolerance and offers long-term immune modification. Traditional subcutaneous immunotherapy (SCIT) has resulted in several deaths and raised safety concerns. Sublingual immunotherapy (SLIT) is an alternative administration route for allergen-specific immunotherapy. Compared to SCIT, SLIT has a shorter escalation ph...

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