background: studies demonstrated controversial results on subclinical hypothyroidism (sch) regarding lipid profile alteration with or without levothyroxine treatment. the purpose of this study is to investigate the effects of levothyroxine on serum lipids in sch. materials and methods: one hundred patients with sch referred to taleghani hospital in kermanshah were recruited and randomly assigne...

Background It is well documented that overt hypothyroidism is associated with adverse pregnancy outcomes, but studies of subclinical hypothyroidism have demonstrated conflicting results. Objective Thyroid hormones are known to regulate mitochondrial function, and the aim of this study was to examine the possible relationship of subclinical hypothyroidism and mitochondrial dysfunction to adver...

Subclinical hypothyroidism and hyperthyroidism are diagnoses based on laboratory evaluation with few if any clinical signs or symptoms. Subclinical hypothyroidism is defined as an elevation in serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range (0.45-4.5 mIU/L) with normal serum FT4 concentration; subclinical hyperthyroidism is defined as a decrease in serum TSH...

Subclinical hypothyroidism, defined as a mild degree of thyroid dysfunction biochemically, is a common clinical disease. It is marked by elevated serum concentrations of thyroid stim‐ ulating hormone (TSH) and normal serum concentrations of free thyroxine (fT4) and triiodo‐ thyronine (T3). Subclinical hypothyroidism can be divided into two categories, depending on the magnitude of the increase ...

The current controversy over recommendations for thyroid screening during pregnancy has its origins in the 1999 publication of an observational study based on thyroid function analysis of stored secondtrimester serum samples. In this study, 62 children of mothers identified with thyroid-stimulating hormone (TSH) levels greater than the 98th percentile were compared with 124 children of euthyroi...

INTRODUCTION The aim of this study was to estimate the significance of TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) hypothyroidism in women from The Danish General Suburban Population Study (GESUS) on the number of children born, the number of pregnancies, and the number of spontaneous abortions. METHODS Retrospective cross sectional study of 11254 women participating in G...

The present investigation was conducted to study the contributive role of clinical and subclinical hypothyroidism in causing dyslipidemia. A total of 220 clinical hypothyroidism patients, 146 subclinical hypothyroids and 200 euthyroid controls, with a mean age of 39 years (range25 – 55 years) were included. The thyropropin, triiodothyronine and thyroxine levels of the patients were assayed by e...

OBJECTIVE To assess the iodine nutritional status and investigate the prevalence of thyroid diseases in a community population in Chengdu, China. METHODS Eighty school-age children were randomly selected for measurements of urinary iodine concentration. A total of 1500 residents over the age of 18 who had lived in Chengdu for more than 5 years were selected by stratified cluster sampling. Ser...

Background: The decision about whether to screen patients for subclinical hypothyroidism (SCH) is clouded by inconsistent evidence of association of dyslipidemia and other risk factors of cardiovascular disease with SCH and also any benefit from early treatment. Objective: To determine whether the known risk factors of cardiovascular disease such as hypertension, increase in fasting blood gluco...

BACKGROUND Subclinical thyroid dysfunction has been implicated as a risk factor for cognitive decline in old age, but results are inconsistent. We investigated the association between subclinical thyroid dysfunction and cognitive decline in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). METHODS Prospective longitudinal study of men and women aged 70-82 years with pre-e...