In an attempt to dissect the mechanism of Strychnos nuxvomica, a commonly used Chinese folk medicine in the therapy of liver cancer, the cytotoxic effects of four alkaloids in Strychnos nux-vomica, brucine, brucine N-oxide, strychnine, and isostrychnine, on human hepatoma cells (HepG2) were screened by 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyl-tetrasolium bromide (MTT) assay. Brucine, among the ...

AIM OF THE STUDY The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also de...

In an attempt to dissect the mechanism of Strychnos nux-vomica, a commonly used Chinese folk medicine in the therapy of liver cancer, the cytotoxic effects of four alkaloids in Strychnos nux-vomica, brucine, brucine N-oxide, strychnine, and isostrychnine, on human hepatoma cells (HepG2) were screened by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrasolium bromide (MTT) assay. Brucine, among th...

Thousands of plant species rely on ants to disperse their seeds, including many South American epiphytes and vines, which, apart from minimizing competition among seedlings, may also reduce competition among different plant species (Handel & Beattie, 1990). The lianas of the Genus Strychnos (Loganiaceae) are recognized as having fruits with highly poisonous seeds containing strychnine in the in...

........................................................................................................................................ xvi CHAPTER ONE ..................................................................................................................................... 1 1.0 INTRODUCTION ..............................................................................................