Phosphocholines, Platelet Stimulating Activity, Antiphytoviral Activity 1-substituted 2-0-hexadecylglycero-3-phosphocholines and some structural analogues were tested for their biological activity on two entirely different test systems: human thrombocytes and potato virus X in tobacco plants. Structural prerequisites for a high activity in both systems are the alkyl glyceryl ether structural el...

Members of the major histocompatibility complex (MHC) class I family of proteins are well known for their central role in the adaptive immune system, where they present self and non-self peptides for immune surveillance. Although the brain has been long considered immune privileged, in part because of an apparent lack of neuronal MHC class I, it has since been shown that MHC class I proteins ar...

Inhibitory transmission through the neurotransmitter γ-aminobutyric acid (GABA) shapes network activity in the mammalian cerebral cortex by filtering synaptic incoming information and dictating the activity of principal cells. The incredibly diverse population of cortical neurons that use GABA as neurotransmitter shows an equally diverse range of mechanisms that regulate changes in the strength...

A current model posits that cofilin-dependent actin severing negatively impacts dendritic spine volume. Studies suggested that increased cofilin activity underlies activity-dependent spine shrinkage, and that reduced cofilin activity induces activity-dependent spine growth. We suggest instead that both types of structural plasticity correlate with decreased cofilin activity. However, the mechan...

This report analyses the role of neuronal activity in shaping the axonal arborizations of sensory neurons from individually identified filiform hairs on the prosternum of locusts (Locusta migratoria), and their connections with a pair of identified interneurons (A4I1). Afferents from lateral filiform hairs terminate in the ipsilateral neuropil and connect only with the ipsilateral interneuron i...

1 in Drosophila 2 3 Authors: Matthew C. W. Oswald1*, Paul S. Brooks1, Maarten F. Zwart2, Amrita Mukherjee1, 4 Ryan J. H. West3, Khomgrit Morarach1, Sean T. Sweeney3, Matthias Landgraf1* 5 *Correspondence to: [email protected] and [email protected] 6 7 8 Affiliations: 9 1 University of Cambridge, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, 10 United Kingdom 11 2 HHMI Janelia Researc...

Observations from different brain areas have established that the adult nervous system can undergo significant experience-related structural changes throughout life. Less familiar is the notion that morphological plasticity affects not only neurons but glial cells as well. Yet there is abundant evidence showing that astrocytes, the most numerous cells in the mammalian brain, are highly mobile. ...

background: resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (dha), make it as a good candidate for designing and development of the new anticonvulsant medications. methods: ten dha-based...