INTRODUCTION Dyslipidemia is one of the most common complications of diabetes mellitus, significantly contributing to cardiovascular morbidity and mortality in diabetic patients. Peucedanum pastinacifolium Boiss. & Hausskn. is commonly used as an antihyperlipidemic vegetable in Iranian folk medicine. MATERIAL AND METHODS In this study, we examined a hydroalcoholic extract of the aerial parts ...

1-methylnicotinamide (MNA) is a primary metabolite of nicotinamide. In recent years several activities of MNA have been described, such as anti-inflammatory activity in skin diseases, induction of prostacyclin synthesis via COX-2, aortal endothelium protection in diabetes and hypertriglyceridaemia and increased survival rate of diabetic rats. 1-methylnicotinamide was also suggested to protect p...

Changes in NO activity may play an important role in the early increase in microvascular flow that has been implicated in the pathogenesis of diabetic microangiopathy. We assessed, in the in situ spinotrapezius muscle preparation of 6 weeks' streptozotocin-diabetic rats (n = 6) and of age-matched controls (n = 8), basal inside diameters of A2-A4 arterioles and the reactivity to topically applie...

Metformin has been used for the treatment of diabetes, whereas atorvastatin reduces the incidence of atherosclerosis and ischemic heart disease. Therefore, combined treatment with meformin plus atorvastatin may be beneficial in diabetic patients associated with cardiac disease. The present study was designed to evaluate the combination therapy of metformin and atorvastatin on streptozotocin-ind...

the study aimed to investigate the protective effects of crocin (cro) against streptozotocin (stz)-induced oxidative damage in rat striatum. animals were randomly divided into four groups (five each). group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). group 2 (stz-lesioned or lesion) were injected with icv-stz (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ...

the aim of this study was to investigate the effects of ethanolic extract of the whole plant of phyllanthus rheedii wight p.rheedii as antihyperglycemic, antihyperlipidemic and antioxidant effect in streptozotocin (stz) induced diabetic rats. male wistar rats were administered p.rheedii (250 mg/kg) orally for 21 days and blood glucose level was measured weekly. at the end of 21 days, the serum ...

background: herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. objective: the hypoglycemic effect of caraway ethanolic extract (carum carvi l.) was investigated in normal and streptozotocin-induced diabetic rats. methods: intraperitoneal administration of caraway ethanolic extract seeds (0.1, 0.2, 0.4 and 0.6 g/kg body wt.) on the ...

abstract          background and objective: according to iranian, asian, indian, and chinese traditional medicine, basil is used in the treatment of different diseases. in this study, the effect of basil on lowering the blood glucose was examined in healthy and diabetic rats.         methods: sixty wistar rats were divided into a control group(n=10), a basil receiving group (n=20) and a diabeti...

background and objective: cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. in this study, the effect of chronic administration of tribulus terrestris (tt) feeding was studied on aortic reactivity of streptozotocin (stz)-diabetic rats and some underlying mechanisms were investigated.    materials and methods: male diabetic rats receive...

background & objectives: streptozotocin (stz) is used for induction of type-1 diabetes mellitus in animal models. its beta-cytotoxic action results in sudden release of insulin leading to severe hypoglycaemia and even mortality. however, its sensitivity varies with species. present investigation was aimed at studying stz induced acute clinical effects in rabbits. methods: streptozotocin@ 65...