Biology is replete with examples of protein-induced DNA bending, yet the forces responsible for bending have been neither established nor quantified. Mirzabekov and Rich proposed in 1979 that asymmetric neutralization of the anionic phosphodiester backbone by basic histone proteins could provide a thermodynamic driving force for DNA bending in the nucleosome core particle [Mirzabekov, A. D., & ...

A freebase cocaine-smoking woman developed relapsing fever, bronchoconstriction, arthralgias and weight loss. Pulmonary infiltrates, arthritis, microhaematuria, pruriginous skin rash and mononeuritis multiplex were later added to the clinical picture. Both skin and muscle biopsies showed eosinophilic angiitis. Improvement or worsening of her clinical picture repeatedly coincided with avoidance ...

a 56-year-old woman came in with abdominal pain, nausea, vomiting, fever, 15 kg weight loss and accelerated asthma for which she had used zafirlukast and a high dose of prednisolone. during taper down of her prednisolone, her condition deteriorated. she developed generalized wheezing, diffuse abdominal pain, and left foot drop. lab examination revealed eosinophilia, elevated red cell sedimentat...

ly, Alexander’s creation of a pattern language can be framed as an instance of research, where an initial interest, in this case the quality of life in designed spaces, leads to a theory in a bottom-up process. From this perspective, Alexander’s work appears similar to the methodological considerations by Glaser and Strauss (1965, 1967), two sociologist, who, when confronted with the task of st...

Introduction The Schmitt revival has generated many interpretations of Schmitt—some on the left, others on the right—and has brought forth, as well, a variety of views about the relationship of Schmitt's Nazism and Anti-Semitism to the core of his political thought. But Heinrich Meier occupies a unique place in the new Schmittean canon. Before coming to Schmitt as a scholarly preoccupation, Mei...

Sirs, Churg-Strauss syndrome (CSS) is a rare disorder characterized by asthma, eosinophilia and systemic vasculitis (1). Three different phases can usually be recognized in CSS: asthma and atopic allergies such as rhinitis may precede of months, and sometimes of several years, the development of an eosinophilic infiltrative disease with eosinophilic pneumonia or gastro-enteritis followed by the...