Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To observe how an aging phenotype interacts with and affects the pathological intracellular accumulation of hyperphosphorylated tau, the tauopathy mouse model pR5 (expressing P301L mutant human tau) was back-crossed more than ten times onto a senescence-accelerated SAMP8 background to establish the new str...

A growing body of evidence has demonstrated amyloid plaques in aged brain; however, little attention has been given to amyloid precursor protein (APP) processing machinery during the healthy aging process. The amyloidogenic and non-amyloidogenic pathways, represented respectively by β- and α-secretases (BACE and TACE), are responsible for APP cleavage. Our working hypothesis is that the normal ...

Amendments are frequently added to agricultural soils to increase organic matter content. In this study, we examined the influence of alperujo, an olive oil mill waste, on the availability of two triazine herbicides, terbuthylazine and atrazine, in two different sandy soils, one from Sevilla, Spain, and the other from Minnesota. The effect of aging on herbicide sorption and bioavailability was ...

The mechanical response of alginate rafts formed by mixing liquid alginate antacid medication (Gaviscon Extra Strength Liquid Antacid) with acidic solutions was investigated by deforming isolated rafts in a shear rheometer. As rafts were deformed to varying magnitudes of applied strain, rheological parameters were identified and related to the overall strength, durability, and recoverability of...

Carbon steels can be heat treated to produce different microstructural variations and mechanical properties. At high temperatures the material plasticity strength influenced by diffusional effects like Portevin-Le Chatelier effect, leading a commonly observed increased at elevated temperatures. The are chemical composition, but also treatment history that affects local composition especially co...

In this study, the working environment of GH4720Li alloy was simulated using a dynamic compression test with strain rate range 0.01–4000 s-1 and temperature 20–1000 °C, its mechanical properties under operating conditions were studied. Based on signifi cant volume data, it observed that there an abnormal stress peak in owing to third aging. The aging behavior is irregular bell-shaped curve. add...

Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer's disease amyloid beta (Abeta) peptides. NEP-deficient mice possess increased levels of brain Abeta(1-40) and Abeta(1-42). The objective of this study was to determine whether tissue NEP specific activity differs according to age and/or across mouse strains, especially those strains predispose...

a stroke of irony that lifespan — the principal phenotype used to search for aging genes — is a terrible phenotype for genetic analysis. Lifespan has relatively low heritability under most conditions, and it is affected by chronic, age-related diseases that confound its use as a biomarker of aging. If the majority of aging genes are pleiotropic, as proposed by the evolutionary theory of aging, ...