Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase (MMP) that was cloned on the basis of differential expression in benign and malignant breast tumors. This MMP has a unique processing mechanism and substrate specificity. Unlike previously characterized MMPs that are secreted as inactive zymogens, STR-3 is processed within the constitutive secretory pathway and secreted ...

The cortico-striato (Str)-globus pallidus external segment (GPe) projection plays major roles in the control of neuronal activity in the basal ganglia under both normal and pathological conditions. The present study used rat brain-slice preparations to address our hypothesis that the gain of this disynaptic projection is dynamically controlled by activations of short-term plasticity mechanisms ...

Functional short tandem repeats (STR) are polymorphic in the population, and the number of repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR in IGF1 promoter has been extensively studied for its association with IGF1 concentration in blood and various clinical traits and represents an important eSTR. We previously used an in-vitro luciferase reporter model to...

BACKGROUND Sensitivity to mold has been associated with asthma incidence, persistence, and severity. OBJECTIVE To examine the relationship between skin test reactivity (STR) to molds and specifically to Alternaria and asthma severity in a group of ethnically diverse children in Connecticut. METHODS Demographics and STR to 14 local allergens, including Alternaria, Penicillium, and mold mix, ...

Second generation sequencing (SGS) may revolutionize the field of forensic STR typing. Two of the essential requirements for implementation of an SGS based approach for forensic investigations are (1) establishment of adequate frequency databases and (2) adoption of a new STR nomenclature. We report the STR sequences and allele frequencies of three STR loci: D3S1358, D12S391 and D21S11 in 197 u...

Short tandem repeats (STRs) are highly mutable genetic elements that often reside in regulatory and coding DNA. The cumulative evidence of genetic studies on individual STRs suggests that STR variation profoundly affects phenotype and contributes to trait heritability. Despite recent advances in sequencing technology, STR variation has remained largely inaccessible across many individuals compa...

ELENA MIHAELA CARAUSU1, VIOLETA TRANDAFIR2,3*, LAURA GHIBU4,5*, OVIDIU STAMATIN6, LAURA ELISABETA CHECHERITA7 1Grigore T. Popa University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Management and Public Health Dentistry, 16 Universitatii Str, 700115, Iasi, Romania 2 Grigore T. Popa University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Oral and M...

This paper presents the development of a Genetic Algorithm Supervisory Loop (GASL) to enhance the performance of Adaptive Controllers in the Self Tuning Regulator (STR) framework. The GASL is designed to tune the identification model and control parameters to achieve an optimum performance of the process. The STR controller used to demonstrate the technique effectiveness is a real time Proporti...

FELICIA DRAGAN1, IRINA KACSO2, FLAVIA MARTIN2*, GHEORGHE BORODI2, IOAN BRATU2, MARCEL COSTULEANU3, IOAN GABRIEL SANDU4,5*, VLADIMIR POROCH6,7 1 Oradea University, Faculty of Medicine and Pharmacy, 1 Armatei Romane Str., 410087, Oradea, Romania 2 National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Str., 400293, Cluj Napoca, Romania, 3 Grigore T. P...