Time-dependent reliability-based design optimization (RBDO) has been acknowledged as an advance optimization methodology since it accounts for time-varying stochastic nature of systems. This paper proposes a time-dependent RBDOmethod considering both of the time-dependent kinematic reliability and the time-dependent structural reliability as constrains. Polynomial chaos combined with the moving...

BACKGROUND Design of drug combination cocktails to maximize sensitivity for individual patients presents a challenge in terms of minimizing the number of experiments to attain the desired objective. The enormous number of possible drug combinations constrains exhaustive experimentation approaches, and personal variations in genetic diseases restrict the use of prior knowledge in optimization. ...

Discrete stochastic models in continuous time are the simplest way to turn survival analysis of an ecological system into a simulation of that system. They build models most faithful to a picture of individuals making choices which affect each other. This article describes how rules for individual behavior can construct a simulation of a population. It argues that, within the context of discret...

Correspondence: massimo. [email protected] Department of Physics, Theory Division, CERN, 1211 Geneva 23, Switzerland Abstract Stochastic backgrounds or relic gravitons, if ever detected, will constitute a prima facie evidence of physical processes taking place during the earliest stages of the evolution of the plasma. The essentials of the stochastic backgrounds of relic gravitons are hereby i...

This paper deals with the problem of control of deterministic, stochastic and fuzzy systems with a fixed termination time and fuzzy constraints imposed on controls and states. Constrains imposed on the system are given as membership functions of particular fuzzy sets. Transition functions for controlled systems are given as a matrix of transitions between states for a deterministic object, a ma...