Germ-line mutations in the LKB1 gene on chromosome 19p are responsible for most cases of the Peutz-Jeghers syndrome, in which intestinal hamartomas are associated with elevated risks of several cancer types, including breast cancer. We have evaluated the role of somatic mutations in LKB1 in breast cancer. Of 40 informative primary breast cancers, 3 showed loss of heterozygosity on chromosome 19...

Peutz-Jeghers syndrome (PJS) is an extremely rare autosomal dominant hereditary disease characterized by the growth of hamartomatous polyps in gastrointestinal tract, mucocutaneous pigmented macules and increased risk malignant neoplasms various localizations. In most cases development PJS associated with presence a mutation STK11 gene, but not all patients have this mutation. This review prese...

Background Mutations in tumor suppressor STK11/LKB1 are associated with negative predictive and prognostic impact NSCLC patients receiving immune checkpoint inhibitors (CPI) several published cohorts, although there have been some conflicting reports on the association of such mutations patient outcomes this setting [1–9]. tumors characterized by a suppressive micro-environment devoid cytotoxic...