Whether a change in myocardial eontractihty is accompanied by a change in diastolic extensibility was studied by altering stimulation frequency, including paired stimulation, as the inotropic intervention. Isometric and isotonic contractions of isolated cat papillary muscles were examined. Apparent changes in diastolic extensibility were observed with paired stimulation in isometric preparation...

243 August 2013 S PINAL cord stimulation was first described in 1967 in an intriguing case report provided by Shealy et al.1 This first case involved the relief from cancerrelated pain using a surgically implanted electrode sutured to the dura to provide stimulation of the dorsal columns. Although the entire treatment was only for approximately 1 day before the patient’s demise, stimulation usi...

BACKGROUND Previous studies have reported that high-frequency stimulation (HFS) in the nucleus accumbens (NAc) is a potential treatment modality for drug craving and relapse. We aimed to explore the electrophysiological changes in reward-related brain regions during NAc stimulation and reveal the effects of stimulation frequency and target changes on NAc neuronal activities. MATERIAL/METHODS ...